Circadian neurons in the lateral habenula: Clocking motivated behaviors
| Autor: | Jorge E. Mendoza |
|---|---|
| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty [SDV]Life Sciences [q-bio] Clinical Biochemistry Circadian clock CLOCK Proteins Toxicology Biochemistry 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Dopamine Internal medicine Monoaminergic medicine Animals Humans Circadian rhythm Biological Psychiatry ComputingMilieux_MISCELLANEOUS Neurons Pharmacology Habenula Motivation Depression Suprachiasmatic nucleus Circadian Rhythm PER2 CLOCK 030104 developmental biology Endocrinology Light effects on circadian rhythm Psychology Neuroscience hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior Pharmacology Biochemistry and Behavior, Elsevier, 2017, 162, pp.55-61. ⟨10.1016/j.pbb.2017.06.013⟩ |
| ISSN: | 0091-3057 |
| Popis: | The main circadian clock in mammals is located in the hypothalamic suprachiasmatic nucleus (SCN), however, central timing mechanisms are also present in other brain structures beyond the SCN. The lateral habenula (LHb), known for its important role in the regulation of the monoaminergic system, contains such a circadian clock whose molecular and cellular mechanisms as well as functional role are not well known. However, since monoaminergic systems show circadian activity, it is possible that the LHb-clock's role is to modulate the rhythmic activity of the dopamine, serotonin and norephinephrine systems, and associated behaviors. Moreover, the LHb is involved in different pathological states such as depression, addiction and schizophrenia, states in which sleep and circadian alterations have been reported. Thus, perturbations of circadian activity in the LHb might, in part, be a cause of these rhythmic alterations in psychiatric ailments. In this review the current state of the LHb clock and its possible implications in the control of monoaminergic systems rhythms, motivated behaviors (e.g., feeding, drug intake) and depression (with circadian disruptions and altered motivation) will be discussed. |
| Databáze: | OpenAIRE |
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