Stability of tacrolimus (FK 506) and cyclosporin G in whole blood
| Autor: | Donald A. Giacherio, Brian C. Hunter, Deirdre R. Fidler, Thomas M. Annesley |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
medicine.medical_specialty Chemistry Tacrolimus Surgery Animal science Drug Stability Fluorescence Polarization Immunoassay Freezing medicine Fluorescence polarization immunoassay Cyclosporine Humans Pharmacology (medical) Drug Monitoring Incubation Immunosuppressive Agents Whole blood Cyclosporin G |
| Zdroj: | Therapeutic drug monitoring. 17(4) |
| ISSN: | 0163-4356 |
| Popis: | The stability of two new immunosuppressants, tacrolimus and cyclosporin G (CsG), was evaluated in whole blood following incubation of patient specimens at ambient temperature or 4 degrees C for time periods of 2 (48 h) and 7 days (168 h) after collection. No decrease in CsG concentrations was noted over a 7-day period for specimens stored at either ambient temperature or 4 degrees C. For tacrolimus, the concentrations of drug in whole blood stored at ambient temperature for 7 days had a slight downward trend. At 7 days, the ratio of tacrolimus concentrations to day zero concentrations ranged from 0.86 to 1.15, with a mean decrease of 5%. However, these changes are within the published precision characteristics of the tacrolimus immunoassay. Evaluation of a smaller group of whole blood specimens provided evidence of adequate stability of these two drugs over a 13-day period. |
| Databáze: | OpenAIRE |
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