Dopexamine hydrochloride in septic shock
| Autor: | Konrad Reinhart, Donald L. Bredle, L. Hannemann, Gero Wallenfang, Andreas Meier-Hellmann |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pulmonary and Respiratory Medicine
Agonist Adult Male medicine.drug_class Dopamine Dopexamine Cardiac index Hemodynamics Critical Care and Intensive Care Medicine Oxygen Consumption medicine Humans Prospective Studies APACHE Septic shock business.industry Adrenergic beta-Agonists Middle Aged medicine.disease Shock Septic Tissue oxygenation Anesthesia Shock (circulatory) Dopexamine hydrochloride Dopamine Agonists Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Chest. 109(3) |
| ISSN: | 0012-3692 |
| Popis: | Objective To test whether dopexamine hydrochloride, by its β 2 -adrenoceptor and dopaminergic 1 (DA 1 ) and dopaminergic 2 (DA 2 ) agonistic properties, can improve oxygen consumption ( V ˙ o 2 ) in hyperdynamic patients with septic shock. Design Prospective, single-cohort study. Setting ICU, university hospital. Patients Twenty-nine postoperative, hemodynamically stabilized, hyperdynamic patients with septic shock. Interventions Short-term application (30 min) of dopexamine hydrochloride at a dose of 2 μg/kg/min. Measurements Complete hemodynamic profile with O 2 transport-related variables at baseline, 30 min after starting the dopexamine infusion, and 30 min after stopping the infusion. Main results The dopexamine infusion resulted in significant increases in cardiac index (17%) (p 2 delivery (Do 2 ) (16%) (p |
| Databáze: | OpenAIRE |
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