Investigating the effect of punch geometry on high speed tableting through radial die-wall pressure monitoring
| Autor: | Sameh Abdel-Hamid, Gabriele Betz |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Time Factors
Materials science Drug Compounding Compaction Pharmaceutical Science Geometry General Medicine Wall pressure Elasticity Excipients Tableting Dwell time Pharmaceutical Preparations Tensile Strength Ultimate tensile strength Powder bed Pressure Cylinder stress Powders Elasticity (economics) Tablets |
| Zdroj: | Pharmaceutical Development and Technology. 18:46-54 |
| ISSN: | 1097-9867 1083-7450 |
| Popis: | Dwell time mainly depends on punch geometry, so some tableting problems such as capping and lamination could occur at high speed compaction. Robust tools are required to monitor the interaction of punch tip and powder bed at these high speeds. Our aim was to investigate the effect of punch geometry (flat and standard concave) on powder compaction at high speed using radial die-wall pressure (RDWP) as a monitoring tool. Instrumented die guided by compaction simulation was applied for five materials with different compaction behaviors. Flat-faced punch showed higher residual, maximum die-wall pressures, and axial stress transmission than concave punches, p |
| Databáze: | OpenAIRE |
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