Two New Anti-Tumor Promoting Serratane-Type Triterpenoids from the Stem Bark ofPicea jezoensisvar.jezoensis
| Autor: | Harukuni Tokuda, Reiko Tanaka, Katsuhiko Minoura, Yohei Ishikawa, Shunyo Matsunaga, Toshifumi Minami |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Herpesvirus 4
Human Skin Neoplasms Stereochemistry Pharmaceutical Science DMBA Analytical Chemistry Inhibitory Concentration 50 Mice Triterpene Drug Discovery Animals Picea Antigens Viral Anticarcinogen Picea jezoensis Pharmacology chemistry.chemical_classification Mice Inbred ICR Papilloma Plant Stems biology Plant Extracts Organic Chemistry Biological activity biology.organism_classification Antineoplastic Agents Phytogenic Molecular biology Triterpenes In vitro Terpenoid Specific Pathogen-Free Organisms Complementary and alternative medicine chemistry visual_art Plant Bark visual_art.visual_art_medium Tetradecanoylphorbol Acetate Molecular Medicine Female Bark Phytotherapy |
| Zdroj: | Planta Medica. 69:1041-1047 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2003-45153 |
| Popis: | Two new serratane-type triterpenoids, 1 and 2, were isolated from the stem bark of Picea jezoensis Carr. var. jezoensis (Pinaceae). Their structures were determined to be 3beta-methoxyserrat-13-en-21beta-ol (1) and 13beta, l4beta-epoxy-3beta-methoxyserratan-21beta-ol (2) on the basis of spectroscopic methods and partial syntheses. Compounds 1 and 2 and their acetates were screened as potential anti-tumor promoters by using the in vitro short-term 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay. IC50 value evaluation showed that compound 1 was more effective than others. In addition, compounds 1 and 2 were examined for anti-tumor promoting activities in a two-stage carcinogenesis assay of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. Compounds 1 and 2 exhibited significant anti-tumor promoting effects on mouse skin carcinogenesis. |
| Databáze: | OpenAIRE |
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