Pulmonary Function in Preterm Infants Following Treatment With Intravenous Indomethacin
| Autor: | John E. O'Loughlin, Nunzia S. Fatica, Barbara S. Lewis, Rebecca Cooper, Mary Allen Engle, Peter A. M. Auld, Constance Cirrincione, Aaron R. Levin, Alfred N. Krauss, Howard T. Thaler |
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| Rok vydání: | 1989 |
| Předmět: |
Respiratory distress
Heart disease business.industry Hyaline Membrane Disease Indomethacin Respiratory disease Infant Newborn Pulmonary compliance medicine.disease Respiration Artificial Pulmonary function testing Low birth weight medicine.anatomical_structure Anesthesia Ductus arteriosus Pediatrics Perinatology and Child Health medicine Humans Arterial blood medicine.symptom business Ductus Arteriosus Patent Lung Infant Premature |
| Zdroj: | Archives of Pediatrics & Adolescent Medicine. 143:78 |
| ISSN: | 1072-4710 |
| Popis: | • Pulmonary function tests, including measurements of arterial blood gas levels, total pulmonary compliance, and arterial-alveolar oxygen ratios, were performed in 38 ventilator-dependent preterm infants with respiratory distress syndrome who weighed less than 1500 g at birth. Twenty-seven had a physiologically significant patent ductus arteriosus (PDA). Twelve were assigned at random to receive three doses of intravenous indomethacin, 0.2 mg/kg per dose, on the fourth day of life. This treatment resulted in ductal closure in seven infants by the seventh day of life. Another concurrently observed group of 15 infants with PDA received no indomethacin. A third group of 11 infants lacked evidence of a PDA. Pulmonary function in the infants who received indomethacin did not differ significantly from that in the other two groups. (AJDC1989;143:78-81) |
| Databáze: | OpenAIRE |
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