Anti-inflammatory activity of the crude extract from the fruits of Pterodon emarginatus Vog
| Autor: | Jairo Kenupp Bastos, S J Sarti, Lucélia R.G Caputo, Kensuly C. M. Patrício, Marcos V. J. Barbosa, Luciano P Ferreira, José Carlos Tavares Carvalho, Jayme Antonio Aboin Sertié |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Nystatin medicine.drug_class Anti-Inflammatory Agents Pharmacognosy Carrageenan Anti-inflammatory law.invention Mice chemistry.chemical_compound law Edema Drug Discovery medicine Animals Pterodon emarginatus Rats Wistar Pharmacology Plants Medicinal Dose-Response Relationship Drug biology Traditional medicine Plant Extracts business.industry Dextrans Fabaceae medicine.disease biology.organism_classification Rats Disease Models Animal chemistry Fruit Granuloma medicine.symptom Phytotherapy business Histamine medicine.drug |
| Zdroj: | Journal of Ethnopharmacology. 64:127-133 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/s0378-8741(98)00116-0 |
| Popis: | The vegetal species Pterodon emarginatus Vog. (Leguminosae/Papilonaceae), popularly known in Brazil as ‘sucupira branca’, is widely used by domestic medicine as an anti-inflammatory. From these observations, the hexanic crude extract (HCE) of the fruits was obtained and submitted for assessment of its anti-inflammatory activity. For this purpose, the following tests were used: (1) Determination of ED50 and LD50; (2) Paw edema induced by carrageenin, dextran, histamine and nystatin; (3) Peritonitis caused by carrageenin and (4) Granuloma test. The ED50 (oral) in the edema induced by carrageenin was 500 mg/kg, and LD50 (oral) was 4.02 g/kg. In the edema caused by nystatin, there was a significant inhibition by 45% (P |
| Databáze: | OpenAIRE |
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