Non-thermal plasma-treated solution demonstrates antitumor activity against pancreatic cancer cells in vitro and in vivo
| Autor: | Claus-Dieter Heidecke, Lars Ivo Partecke, Christine Hackbarth, Wolfram von Bernstorff, Kim Rouven Liedtke, André Kaeding, Sander Bekeschus, Thomas von Woedtke, Jens-Peter Kuehn |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Plasma Gases Cell Survival Science viruses Antineoplastic Agents Apoptosis Mice Transgenic Article Mice 03 medical and health sciences 0302 clinical medicine In vivo Cell Line Tumor Pancreatic cancer Blood plasma Animals Humans Medicine Viability assay Cell Proliferation Multidisciplinary business.industry Cell growth Cancer medicine.disease Magnetic Resonance Imaging Pancreatic Neoplasms 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell Cancer research Reactive Oxygen Species business Oxidation-Reduction Biomarkers |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-08560-3 |
| Popis: | Pancreatic cancer is associated with a high mortality rate. In advanced stage, patients often experience peritoneal carcinomatosis. Using a syngeneic murine pancreatic cancer cell tumor model, the effect of non-thermal plasma (NTP) on peritoneal metastatic lesions was studied. NTP generates reactive species of several kinds which have been proven to be of relevance in cancer. In vitro, exposure to both plasma and plasma-treated solution significantly decreased cell viability and proliferation of 6606PDA cancer cells, whereas mouse fibroblasts were less affected. Repeated intraperitoneal treatment of NTP-conditioned medium decreased tumor growth in vivo as determined by magnetic resonance imaging, leading to reduced tumor mass and improved median survival (61 vs 52 days; p |
| Databáze: | OpenAIRE |
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