The nucleoprotein complement-fixation test in the diagnosis of systemic lupus erythematosus
| Autor: | Lois A. Simonton, Louis H. Muschel, Donald M. Marcus, Raymond Captain Scalettar |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
Pathology
medicine.medical_specialty Anti-nuclear antibody business.industry Phagocytosis Cell Complement Fixation Tests Gamma globulin General Medicine Complement fixation test Nucleoprotein Antigen-Antibody Reactions Cell nucleus medicine.anatomical_structure Nucleoproteins Immunology medicine Humans Lupus Erythematosus Systemic business Anti-SSA/Ro autoantibodies |
| Zdroj: | The New England journal of medicine. 263 |
| ISSN: | 0028-4793 |
| Popis: | A gamma-globulin factor in the serum of patients with systemic lupus erythematosus that reacts with isolated cell nuclei1 or nucleoprotein2 , 3 has been detected in many ways.4 The standard method of demonstrating this factor remains the L.E.-cell test, which is a complex process involving the reaction of a component of the cell nucleus with the serum lupuserythematosus factor and subsequent phagocytosis of the altered nuclear material.5 Other methods for the detection of antinuclear antibodies have proved useful both clinically and in immunologic investigations. These include the identification of gamma globulin present on cell nuclei by measurement of its ability to decrease . . . |
| Databáze: | OpenAIRE |
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