Juvenile lupus: Different clinical and serological presentations compared to adult lupus in Egypt
| Autor: | Dalia F. Mohamed, Mohammed Abd El Moniem Teama, Amina Badr El-Din Abdel Aziz, Rasha Hassan El-Owaidy, Sameh Abdel-Moteleb Hassan, Noha Hussein Shedid |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
lcsh:Immunologic diseases. Allergy medicine.medical_specialty Urinary system SLE Lupus nephritis Juvenile Serology 03 medical and health sciences 0302 clinical medicine Rheumatology immune system diseases Internal medicine medicine 030212 general & internal medicine skin and connective tissue diseases 030203 arthritis & rheumatology SLEDAI Lupus anticoagulant Systemic lupus erythematosus business.industry medicine.disease Immunology medicine.symptom lcsh:RC581-607 Malar rash business Nephritis |
| Zdroj: | Egyptian Rheumatologist, Vol 40, Iss 1, Pp 55-58 (2018) |
| ISSN: | 1110-1164 |
| DOI: | 10.1016/j.ejr.2017.04.004 |
| Popis: | Aim of the work: We aimed to evaluate the differences in clinical presentation, serological pattern and disease activity between juvenile and adult-onset of Egyptian systemic lupus erythematosus (SLE) patients. Patients and methods: 160 Egyptian SLE patients (80 Adult-onset and 80 juveniles) were included. Patients records were reviewed for clinical and laboratory evaluation on presentation. Disease activity at onset was assessed using SLE Disease Activity Index (SLEDAI). Results: The mean age of the adult patients was 29.9 ± 7.2 years and of the juvenile cases (12.8 ± 2.1 years). The female:male ratio of the adults was 10:1 while it was 39:1 in the SLE children. The most common clinical presentation among adult SLE was malar rash (75%) followed by articular manifestations (62.5%), while in juveniles, nephritis (78.8%) followed by articular manifestations (71.2%) were the most common. Juvenile patients had more frequent neuropsychiatric (p = 0.015) and hematologic abnormalities (p |
| Databáze: | OpenAIRE |
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