Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway
| Autor: | Mayada R. Farag, Mohamed E. Abd El-Hack, Mustafa Shukry, Nora Ghanem, Samaa M. Bakr, Adil Aldhahrani, Asmaa R. Abou El-khair, Mohamed Mohamed Soliman |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Taurine
Science (General) Apoptosis Pharmacology medicine.disease_cause Lipid peroxidation chemistry.chemical_compound Q1-390 Lactate dehydrogenase Medicine Oxidative injury Multidisciplinary Ipomoea carnea biology business.industry Nuclear factor (erythroid-derived 2)-like 2 Neurotoxicity medicine.disease biology.organism_classification chemistry Toxicity biology.protein Creatine kinase business Oxidative stress |
| Zdroj: | Journal of King Saud University: Science, Vol 33, Iss 8, Pp 101639-(2021) |
| ISSN: | 1018-3647 |
| Popis: | Objectives: The adverse deleterious influences of Ipomoea carnea on brain tissue and Taurine's relative ability to prevent this neurotoxicity have been examined. Methods: We utilized sixty Wistar male rats weighing 1752 g. The rats were allotted into 4 groups of fifteen each: The control group got saline i.p. daily for eight weeks; the Ipomoea carnea extract (ICE) group received ICE (15 mg/kg b.w./day) orally for eight weeks. Taurine-treated rats, in which rats were administered Taurine (200 mg·kg−1, i.p./Day) for 2 months. Taurine + ICE group in which rats were supplemented with (200 mg·kg−1, i.p. Taurine + ICE 15 mg/kg b.w./day orally) for 2 months. Result: The findings indicated that Ipomoea persuaded an increase in lipid peroxidation markers as well as a disruption in antioxidant homeostasis, along with brain and serum cholinesterase (AChE) elevated levels, tumor necrosis factor (TNF), total creatine phosphokinase (CPK), creatine phosphokinase isoenzymes BB (CPK-BB), and lactate dehydrogenase (LDH). A considerable drop (P |
| Databáze: | OpenAIRE |
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