d-Serine, the Shape-Shifting NMDA Receptor Co-agonist
| Autor: | Joseph T. Coyle, Darrick T. Balu, Herman Wolosker |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Agonist Dendritic spine medicine.drug_class Excitotoxicity medicine.disease_cause Receptors N-Methyl-D-Aspartate Biochemistry Article 03 medical and health sciences Cellular and Molecular Neuroscience Glutamatergic 0302 clinical medicine Excitatory Amino Acid Agonists Serine medicine Animals Humans Neurons Chemistry Glutamate receptor Brain General Medicine 030104 developmental biology nervous system Serine racemase Excitatory postsynaptic potential NMDA receptor Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurochem Res |
| ISSN: | 1573-6903 0364-3190 |
| Popis: | Shape-shifting, a phenomenon wide-spread in folklore, refers to the ability to physically change from one identity to another, typically from an innocuous entity to a destructive one. The amino acid D-serine over the last 25 years has "shape-shifted" into several identities: a purported glial transmitter activating N-methyl-D-aspartate receptors (NMDARs), a co-transmitter concentrated in excitatory glutamatergic neurons, an autocrine that is released at dendritic spines to prime their post-synaptic NMDARs for an instantaneous response to glutamate and an excitotoxic moiety released from inflammatory (A1) astrocytes. This article will review evidence in support of these scenarios and the artifacts that misled investigators of the true identity of D-serine. |
| Databáze: | OpenAIRE |
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