Evaluation of the validity of pancreatectomy for very elderly patients with pancreatic ductal adenocarcinoma
| Autor: | Masahiro Shiihara, Wataru Izumo, Ryota Higuchi, Shuichiro Uemura, Takehisa Yazawa, Yutaro Matsunaga, Toru Furukawa, Masakazu Yamamoto |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 030230 surgery Adenocarcinoma Gastroenterology 03 medical and health sciences 0302 clinical medicine Pancreatectomy Internal medicine Medicine Humans Risk factor Aged Retrospective Studies Aged 80 and over business.industry Hazard ratio Odds ratio Vascular surgery medicine.disease Prognosis Pancreatic Neoplasms Survival Rate Cardiothoracic surgery 030220 oncology & carcinogenesis Surgery Neoplasm Recurrence Local business Abdominal surgery Carcinoma Pancreatic Ductal |
| Zdroj: | Langenbeck's archives of surgery. 406(4) |
| ISSN: | 1435-2451 |
| Popis: | The role of pancreatectomy for very elderly patients with pancreatic adenocarcinoma is controversial. This study aimed to clarify the validity of pancreatic resection in octogenarian patients with pancreatic ductal adenocarcinoma. We compared 31 patients aged ≥ 80 years and 548 patients aged < 80 years who underwent pancreatectomy for pancreatic ductal adenocarcinoma and evaluated the relationship between age, clinicopathological factors, recurrence, and outcomes. Postoperative mortality, morbidity, and completion of adjuvant chemotherapy rates did not differ between groups. There were no significant differences in median recurrence–free survival, disease-specific survival, and overall survival between groups (1.0, 2.3, and 2.2 years in patients ≥ 80 years and 1.2, 2.8, and 2.7 years in patients < 80 years; P = 0.67, 0.47, and 0.46, respectively). The median time from recurrence to death of octogenarian patients was significantly shorter than that of younger patients (0.6 vs. 1.1 years, P = 0.0070). In multivariate analysis, age ≥ 80 years (hazard ratio, 1.5), resection of other organs (hazard ratio, 1.8), pathological grade 2/3 (hazard ratio, 1.6), and failure to implement of treatment after recurrence (hazard ratio, 3.6) were independent risk factors for a short time from recurrence to death. Furthermore, age ≥ 80 years (odds ratio, 0.32) was an independent risk factor for the implementation of treatment after recurrence. Pancreatectomy for octogenarians may be acceptable, but median survival time from recurrence to death was shorter due to lower rates of implementation of treatment after recurrence in octogenarian patients. |
| Databáze: | OpenAIRE |
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