Thymol derivatives from the roots of Xerolekia speciosissima an endemic species of the pre-Alpine area
| Autor: | Janusz Malarz, Bogdan Musielak, Natalia Kłeczek, Anna Stojakowska, Maja Kosecka-Strojek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Plant Science
Tribe (biology) medicine.disease_cause 01 natural sciences Biochemistry Syringaldehyde chemistry.chemical_compound 2 6-dimethoxy-p-benzoquinone Inuleae Xerolekia Botany medicine Agar diffusion test monoterpenoids Thymol Novobiocin Chloroform biology thymol derivatives 010405 organic chemistry Asteraceae biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Staphylococcus aureus Agronomy and Crop Science Biotechnology medicine.drug |
| Popis: | A chloroform extract from roots of Xerolekia speciosissima, except for commonly distributed phenolic compounds, i.e.: syringaldehyde and 2,6-dimethoxy-p-benzoquinone, yielded five thymol derivatives. Two of the compounds, namely: 8-hydroxy-9-isobutyryloxy-10-isovaleryloxythymol (1) and 8-hydroxy-9,10-diisovaleryloxythymol (2) have not been previously reported and their structures were elucidated based on 1D and 2D NMR, HRESIMS and other spectral data. Three known thymol derivatives: 8-hydroxy-9,10-diisobutyryloxythymol (3), 7,10-diisobutyryloxy-8,9-epoxythymol isobutyrate (4) and 10-isobutyryloxy-7-isovaleryloxy-8,9-epoxythymol isobutyrate (5) were formerly isolated from other taxa of the Inulae tribe (Asteraceae). Activities of 1 and 5 against Staphylococcus aureus were preliminarily evaluated by Kirby-Bauer disk diffusion method using novobiocin as a positive control. |
| Databáze: | OpenAIRE |
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