The Effect of Altitude Descent on Obstructive Sleep Apnea
| Autor: | Louise Dover, David P. White, Bruce J. Swihart, Michael D. Patz, Mark Spoon, David S. Patz, Richard Corbin |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Colorado Polysomnography Central apnea Critical Care and Intensive Care Medicine Non-rapid eye movement sleep Diagnosis Differential Respiratory disturbance index medicine Humans False Negative Reactions Sleep Apnea Obstructive medicine.diagnostic_test business.industry Altitude Sleep apnea Apnea Middle Aged medicine.disease Sleep Apnea Central respiratory tract diseases Obstructive sleep apnea Apnea–hypopnea index Anesthesia Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Chest. 130:1744-1750 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.130.6.1744 |
| Popis: | The present requirement for "at facility" polysomnograms requires many residents in mountain communities to descend in elevation for sleep testing, which may cause misleading results regarding the severity of obstructive sleep apnea (OSA).Eleven patients with previously undiagnosed sleep apnea living at an altitude2,400 m (7,900 feet) in Colorado underwent diagnostic sleep studies at their home elevation and at 1,370 m (4,500 feet), and 5 of the 11 patients were also studied at sea level.The mean (SE) apnea-hypopnea index (AHI) fell from 49.1 (10.5)/h to 37.0 (11.2)/h on descent to 1,370 m (p = 0.022). In the five patients who traveled to sea level, the AHI dropped from 53.8 (13.2)/h at home elevation to 47.1 (14.8)/h at 1,370 m, and to 33.1 (12.6)/h at sea level (p = 0.018). The reduction in AHI was predominantly a reduction in hypopneas and central apneas, with little change in the frequency of obstructive apneas. Duration of the obstructive apneas lengthened with descent. Of eight patients with an AHI50/h at their home elevation, two patients had their AHI fall to5/h at 1,370 m, and a third patient dropped to5/h at sea level, ie, below many physicians' threshold for providing therapy. Patients with the most severe OSA had the least improvement with descent.Because AHI decreases significantly with descent in altitude, polysomnography is most accurately done at the home elevation of the patient. Descent to a sleep laboratory at a lower elevation may yield false-negative results in patients with mild or moderate sleep apnea. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|