A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium
| Autor: | Nathan A. Ellis, H-H. Sherry Chow, Meghan B Skiba, Wade M. Chew, Peter Lance, Elizabeth T. Jacobs, Jessica A. Martinez, Kathylynn Saboda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adenoma
Male medicine.medical_specialty Colorectal cancer oxylipins chemistry.chemical_element Colorectal adenoma Placebo Gastroenterology Article chemistry.chemical_compound Internal medicine medicine arachidonic acid Humans TX341-641 Prostaglandin E2 selenium Aged colorectal adenoma Nutrition and Dietetics ARA Nutrition. Foods and food supply business.industry Oxylipin Middle Aged medicine.disease Treatment Outcome chemistry colon cancer Celecoxib Dietary Supplements Disease Progression Arachidonic acid Female business Colorectal Neoplasms colorectal neoplasia Selenium Food Science medicine.drug Follow-Up Studies |
| Zdroj: | Nutrients Volume 13 Issue 11 Nutrients, Vol 13, Iss 3877, p 3877 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13113877 |
| Popis: | Oxylipins derived from arachidonic acid (ARA) have been implicated in the development of colorectal adenomas and colorectal cancer. The primary purpose of this work was to determine the relationship between plasma levels of oxylipins and colorectal adenoma characteristics at study entry, as well as with the development of a new adenoma during follow-up within a Phase III adenoma prevention clinical trial with selenium (Sel). Secondarily, we sought to determine whether the selenium intervention influenced plasma oxylipin levels. Four oxylipins were quantified in stored plasma samples from a subset of Sel study subjects (n = 256) at baseline and at 12-months. There were significantly lower odds of an advanced adenoma at baseline with higher prostaglandin E2 (PGE2), with an OR (95% CI) of 0.55 (0.33–0.92), and with 5-hydroxyeicosatetraenoic acid (5-HETE) ((0.53 (0.33–0.94)) and of a large adenoma with higher PGE2 ((0.52 (0.31–0.87)). In contrast, no associations were observed between any oxylipin and the development of a new adenoma during follow-up. Selenium supplementation was associated with a significantly smaller increase in 5-HETE after 12 months compared to the placebo, though no other results were statistically significant. The ARA-derived oxylipins may have a role in the progression of non-advanced adenoma to advanced, but not with the development of a new adenoma. |
| Databáze: | OpenAIRE |
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