Association between exhaled breath condensate nitrate + nitrite levels with ambient coarse particle exposure in subjects with airways disease
| Autor: | J. J. de Hartog, Dimitra Perifanou, Gerard Hoek, AH Mansur, Jon G Ayres, Klea Katsouyanni, Sarah Manney, Juha Pekkanen, Claire Meddings, Anna Karakatsani, Kaarle Hämeri, Antonis Analitis, N. Kotronarou, Richard W Harrison, Ilias G. Kavouras, Harry ten Brink |
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| Přispěvatelé: | Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS |
| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology Particle number Respiratory Tract Diseases 010501 environmental sciences medicine.disease_cause 01 natural sciences chemistry.chemical_compound Pulmonary Disease Chronic Obstructive 0302 clinical medicine Nitrate Medicine Exhaled breath condensate Nitrite Lung Air Pollutants Respiration Particulates Middle Aged 3. Good health Europe Air Pollution Indoor Female Nitrogen Oxides Steroids medicine.medical_specialty Molecular epidemiology [NCEBP 1] 03 medical and health sciences Animal science Air Pollution Humans Cities Particle Size NOx Nitrites 0105 earth and related environmental sciences Asthma Aged Inflammation Nitrates business.industry Public Health Environmental and Occupational Health Environmental Exposure medicine.disease respiratory tract diseases Oxidative Stress 030228 respiratory system chemistry 13. Climate action Particulate Matter business Oxidative stress Biomarkers |
| Zdroj: | Occupational and Environmental Medicine, 69, 663-9 Occupational and Environmental Medicine, 69, 9, pp. 663-9 Occupational and Environmental Medicine, 69(9), 663. BMJ Publishing Group Ltd |
| ISSN: | 1351-0711 |
| DOI: | 10.1136/oemed-2011-100255 |
| Popis: | Item does not contain fulltext OBJECTIVES: Studies of individual inflammatory responses to exposure to air pollution are few but are important in defining the most sensitive markers in better understanding pathophysiological pathways in the lung. The goal of this study was to assess whether exposure to airborne particles is associated with oxidative stress in an epidemiological setting. METHODS: The authors assessed exposure to particulate matter air pollution in four European cities in relation to levels of nitrite plus nitrate (NOx) in exhaled breath condensate (EBC) measurements in 133 subjects with asthma or chronic obstructive pulmonary disease using an EBC capture method developed for field use. In each subject, three measurements were collected. Exposure measurements included particles smaller than 10 mum (PM(10)), smaller than 2.5 mum (PM(2.5)) and particle number counts at a central site, outdoors near the subject's home and indoors. RESULTS: There were positive and significant relationships between EBC NOx and coarse particles at the central sampling sites (increase of 20.4% (95% CI 6.1% to 36.6%) per 10 mug/m(3) increase of coarse particles of the previous day) but not between EBC NOx and other particle measures. Associations tended to be stronger in subjects not taking steroid medication. CONCLUSIONS: An association was found between exposure to ambient coarse particles at central sites and EBC NOx, a marker of oxidative stress. The lack of association between PM measures more indicative of personal exposures (particularly indoor exposure) means interpretation should be cautious. However, EBC NOx may prove to be a marker of PM-induced oxidative stress in epidemiological studies. |
| Databáze: | OpenAIRE |
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