KLINEFELTER'S SYNDROME, A CLINICAL AND CYTOGENIC STUDY IN TWENTY-FOUR CASES
| Autor: | Jane Claffey, Anne P. Forbes, Linda Mantooth, Eric Engel, Klaus Zuppinger |
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| Rok vydání: | 1967 |
| Předmět: |
Adult
Male Peptic Ulcer medicine.medical_specialty Pediatrics Adolescent Endocrinology Diabetes and Metabolism Hypercholesterolemia Coronary Disease Hyperlipidemias Varicose Veins Klinefelter Syndrome Endocrinology Hypothyroidism Internal medicine Diabetes Mellitus medicine Humans Cholecystectomy Obesity Aged S syndrome business.industry General Medicine Middle Aged Female business |
| Zdroj: | Acta Endocrinologica. 54:S5-S48 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.054s005 |
| Popis: | Clinical and cytogenetic studies were made of twenty four patients with Klinefelter's syndrome in order to determine the somatic consequences of X chromosomal overdosage and its effect on the incidence of metabolic and degenerative diseases. Salient features of the group were tall stature, obesity, a high incidence of diabetes mellitus, hyperlipemia, hypercholesterolemia, gall bladder disease, chronic pulmonary infection, peptic ulcer, varicose veins, laboratory indices of hypothyroidism and a disordered personality. There was a striking absence of hypertension, myocardial infarction and rheumatoid arthritis and no case of hyperthyroidism, thyroiditis or gout. Family histories revealed a high incidence of diabetes mellitus in close relatives. Thus the second X chromosome, although it is sequestered in adult life appears to have profound metabolic as well as morphological effects. |
| Databáze: | OpenAIRE |
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