Splicing and Polyadenylation of Human Papillomavirus Type 16 mRNAs
| Autor: | Stefan Schwartz, Chengjun Wu, Naoko Kajitani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Gene Expression Regulation
Viral 0301 basic medicine HPV16 Polyadenylation RNA Splicing viruses Genome Viral Review Biology Heterogeneous-Nuclear Ribonucleoproteins Catalysis Epigenesis Genetic Inorganic Chemistry lcsh:Chemistry Viral Proteins 03 medical and health sciences splicing Viral life cycle Gene expression Humans RNA Messenger Physical and Theoretical Chemistry polyadenylation human papillomavirus Molecular Biology neoplasms lcsh:QH301-705.5 Spectroscopy Genetics Human papillomavirus 16 integumentary system Papillomavirus Infections Organic Chemistry Alternative splicing RNA virus diseases General Medicine female genital diseases and pregnancy complications Computer Science Applications Post-transcriptional modification genomic DNA 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 RNA splicing SR-protein hnRNP |
| Zdroj: | International Journal of Molecular Sciences, Vol 18, Iss 2, p 366 (2017) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 early gene expression program to the late requires a promoter switch, a polyadenylation signal switch and a shift in alternative splicing. A number of cis-acting RNA elements on the HPV16 mRNAs and cellular and viral factors interacting with these elements are involved in the control of HPV16 gene expression. This review summarizes our knowledge of HPV16 cis-acting RNA elements and cellular and viral trans-acting factors that regulate HPV16 gene expression at the level of splicing and polyadenylation. |
| Databáze: | OpenAIRE |
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