Bone status and adipokine levels in children on vegetarian and omnivorous diets
| Autor: | Katarzyna Szamotulska, Grażyna Rowicka, Małgorzata Strucińska, Joanna Gajewska, Jadwiga Ambroszkiewicz, Magdalena Chełchowska, Witold Klemarczyk |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Osteocalcin Adipokine 030209 endocrinology & metabolism Critical Care and Intensive Care Medicine Bone remodeling 03 medical and health sciences 0302 clinical medicine Adipokines N-terminal telopeptide Bone Density Internal medicine Humans Medicine Vitamin D Child Bone mineral 030109 nutrition & dietetics Nutrition and Dietetics Adiponectin biology business.industry Diet Vegetarian Leptin Diet Endocrinology Case-Control Studies Child Preschool Body Composition biology.protein Female Bone Remodeling Energy Intake business Biomarkers Type I collagen |
| Zdroj: | Clinical Nutrition. 38:730-737 |
| ISSN: | 0261-5614 |
| DOI: | 10.1016/j.clnu.2018.03.010 |
| Popis: | Measurements of bone mineral density (BMD) reflect bone status but not the dynamics of bone turnover. Biochemical markers, which show global skeletal activity, were validated for the assessment of bone formation and resorption processes. Adipokines also play a significant role in the regulation of bone metabolism.To assess body composition, bone mineral density, bone turnover markers and adipokine levels in relation to vegetarian and omnivorous diets.The study included 53 vegetarian and 53 omnivorous prepubertal healthy children matched for age and sex (median age 7.0 years). Body composition and BMD were assessed by dual-energy X-ray absorptiometry. 25-hydroxyvitamin D and parathormone levels were measured by chemiluminescence method. Serum carboxy-terminal propeptide of type I collagen (CICP), total osteocalcin (OC) and its forms carboxylated (c-OC) and undercarboxylated (uc-OC), C-terminal cross-linking telopeptide of collagen type I (CTX), leptin and adiponectin levels were determined using immunoenzymatic assays.Both groups of children were comparable in terms of body composition, except for the percentage of fat mass, which was lower (19.24 vs. 21.77%, p = 0.018) in vegetarians. Mean values of total BMD z-score and lumbar spine BMD z-score were lower (-0.583 vs. -0.194, p = 0.009 and -0.877 vs. -0.496, p = 0.019, respectively) in vegetarians compared with omnivores. Serum leptin level was about 2-fold lower (1.39 vs. 2.94 ng/mL, p 0.001) in vegetarians, however, adiponectin concentration was similar in both groups. Vegetarians had similar concentration of 25-hydroxyvitamin D, but higher parathormone (40.8 vs. 32.1 pg/mL, p = 0.015) and CTX (1.94 vs. 1.76 ng/mL, p = 0.077) levels than omnivores. Total osteocalcin and CICP concentrations were comparable in both groups, however, c-OC/uc-OC ratio was higher (1.43 vs. 1.04 ng/mL, p 0.05) in vegetarians. We found positive correlation between c-OC and nutritional parameters adjusted for total energy intake (plant protein, phosphorus, magnesium and fiber intakes) in vegetarian children.Prepubertal children on a vegetarian diet had significantly lower total and lumbar spine BMD z-scores, but absolute values of bone mineral density did not differ. BMD z-scores did not correlate with bone metabolism markers and nutritional variables, but were positively associated with anthropometric parameters. Lower leptin levels in vegetarian children reflect lower body fat. Longitudinal studies are necessary to evaluate the impact of the observed association on bone health at adulthood. |
| Databáze: | OpenAIRE |
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