Decrease in human striatal dopamine D2 receptor density with age: a PET study with [11C]raclopride
| Autor: | Jarmo Hietala, Juha O. Rinne, A. Laihinen, Vesa Oikonen, Pertti Lehikoinen, Erkki Säkö, Kjell Någren, Erkka Syvälahti, Ulla Ruotsalainen |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Aging Extrapyramidal symptoms Dopamine Internal medicine Dopamine receptor D2 Cerebellum Salicylamides medicine Radioligand Humans Carbon Radioisotopes Receptor Aged Raclopride Aged 80 and over Chemistry Receptors Dopamine D2 Dopaminergic Middle Aged Dissociation constant Substantia Nigra Dopamine D2 Receptor Antagonists Endocrinology Neurology Female Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine medicine.drug Tomography Emission-Computed |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0271-678X |
| Popis: | The effect of age on human striatal dopamine D2 receptors was investigated with positron emission tomography (PET) using [11C]raclopride as a radioligand. Twenty-one healthy volunteers aged from 20 to 81 years were studied. An equilibrium method was applied and two separate PET scans with different specific activities of [11C]raclopride were performed. The maximal number of receptors ( Bmax) and their dissociation constant ( Kd) were calculated using Scatchard analysis. There was an age-dependent decline in the Bmax ( r = 0.49; p = 0.02) of striatal D2 receptors while the Kd remained unchanged. The results show that there is an age-related loss of striatal D2 receptors, which, together with other changes in the brain nigrostriatal dopaminergic system, may contribute to extrapyramidal symptoms associated with aging. |
| Databáze: | OpenAIRE |
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