Lipid Profile Changes and Importance of Low Serum α-Lipoprotein Fraction (High-Density Lipoprotein) in Cases With Acute Pancreatitis
| Autor: | Yuksel Altuntas, Mehmet Sokmen, Mehmet Sait Bugdaci, Sayid Shafi Zuhur |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Disease Risk Assessment Gastroenterology Young Adult chemistry.chemical_compound Endocrinology High-density lipoprotein Risk Factors Internal medicine Internal Medicine medicine Humans Triglycerides Aged Aged 80 and over Endoscopic retrograde cholangiopancreatography Hepatology medicine.diagnostic_test Triglyceride business.industry Length of Stay Middle Aged medicine.disease Lipids medicine.anatomical_structure Pancreatitis chemistry Acute Disease Amylases Acute pancreatitis Female Lipoproteins HDL Pancreas Lipid profile business Lipoprotein |
| Zdroj: | Pancreas. 40:1241-1244 |
| ISSN: | 0885-3177 |
| DOI: | 10.1097/mpa.0b013e3182211bbf |
| Popis: | OBJECTIVES Acute pancreatitis (AP) is a common systemic inflammatory disorder of the pancreas. The data related to the lipid changes in patients with AP were insufficient. In this study, we aimed to investigate the relation between high-density lipoprotein (HDL) and the other lipid parameters and the severity of the disease in AP cases. METHODS Seventy-five cases admitted to the Gastroenterohepatology Clinic with diagnosis of AP were included in the study. Ranson scores and Glasgow scores were used for prognosis. Lipid parameters were evaluated for the first 24 hours and after clinic and laboratory remission. RESULTS The causes of the disease among patients included in the study were as follows: 44 biliary origin (58.7%), 14 alcohol dependent (18.7%), 10 idiopathic (13.3%), 6 hyperlipidemic (8%), and 1 endoscopic retrograde cholangiopancreatography dependent (1.3%). Triglyceride (TG) levels of the patients included in the study measured in the first 2 days were significantly higher than TG levels measured after clinic and laboratory remission (P = 0.013). High-density lipoprotein was significantly lower in alcoholic and hypertriglyceridemic AP cases. There was a statistical correlation between HDL and Ranson (P = 0.023). CONCLUSION The low levels of HDL in AP cases during acute attack are associated with severity of the disease. |
| Databáze: | OpenAIRE |
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