Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients

Autor: Florence Bichat, Marc-Antoine Hannappe, Catherine Vergely, Alexandre Meloux, Christine Binquet, Louis Arnould, Charles Guenancia, Yves Cottin, B. Mouhat, Catherine Creuzot-Garcher, Marianne Zeller
Přispěvatelé: Julien, Sabine, Nature Publishing Group, Service d'Ophtalmologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon] (PEC2), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service de Cardiologie [CHU de Dijon], Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
lcsh:Medicine
030204 cardiovascular system & hematology
law.invention
chemistry.chemical_compound
0302 clinical medicine
law
Risk Factors
Macula Lutea
lcsh:Science
Multidisciplinary
Angiography
Middle Aged
Intensive care unit
3. Good health
medicine.anatomical_structure
[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Cardiology
Female
Anatomy
Tomography
Optical Coherence
medicine.medical_specialty
Acute coronary syndrome
Growth Differentiation Factor 15
Article
Angiopoietin-2
Transforming Growth Factor beta1
03 medical and health sciences
Osteoprotegerin
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Internal medicine
medicine
Humans
Acute Coronary Syndrome
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Aged
Retina
business.industry
Length density
lcsh:R
Retinal Vessels
Retinal
Optical coherence tomography angiography
medicine.disease
Interleukin-1 Receptor-Like 1 Protein
chemistry
030221 ophthalmology & optometry
lcsh:Q
sense organs
business
Biomarkers
Blood sampling
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports, 2020, 10 (1), pp.16718. ⟨10.1038/s41598-020-73861-z⟩
Scientific Reports, Nature Publishing Group, 2020, 10, pp.16718. ⟨10.1038/s41598-020-73861-z⟩
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.16718. ⟨10.1038/s41598-020-73861-z⟩
ISSN: 2045-2322
DOI: 10.1038/s41598-020-73861-z
Popis: International audience; We aimed to compare retinal vascular density in optical coherence tomography Angiography (oct-A) between patients hospitalized for acute coronary syndrome (AcS) and control patients and to investigate correlation with angiogenesis biomarkers. patients hospitalized for an acute coronary syndrome (AcS) in the intensive care Unit were included in the "high cardiovascular risk" group while patients without cardiovascular risk presenting in the ophthalmology department were included as "control". Both groups had blood sampling and OCT-A imaging. Retina microvascularization density in the superficial capillary plexus was measured on 3 × 3 mm angiograms centered on the macula. Angiopoietin-2, TGF-β1, osteoprotegerin, GDF-15 and ST-2 were explored with ELISA or multiplex method. Overall, 62 eyes of ACS patients and 42 eyes of controls were included. ACS patients had significantly lower inner vessel length density than control patients (p = 0.004). A ROC curve found that an inner vessel length density threshold below 20.05 mm −1 was moderately associated with AcS. Significant correlation was found between serum levels of angiopoietin-2 and osteoprotegerin, and retinal microvascularization in OCT-A (R = − 0.293, p = 0.003; R = − 0.310, p = 0.001). Lower inner vessel length density measured with oct-A was associated with AcS event and was also correlated with higher concentrations of angiopoietin-2 and osteoprotegerin. In spite of the improvements in diagnosis and treatment of cardiovascular diseases (CVD), aging of population and urbanization make CVD one of the world's major disease burdens 1,2. Indeed, CVD remain a main cause of premature deaths and disability worldwide, with an estimated 16.7 million deaths in 2010, and projections show an overwhelming 23.3 million by 2030 3. Cardiovascular risk factors such as hypertension, hypercholesterolemia, and diabetes mellitus lead to systemic inflammation, vascular and cardiac oxidative stress, which contribute to coronary dysfunction and microvascular impairment 4. Thus, coronary macro and microvascular alterations are closely associated and together contribute to the pathophysiology of myocardial ischemia 5. The assessment of myocardial microvascularization is then of major interest in order to estimate the risk of acute coronary events; however, only invasive procedures, using intra vascular contrast agents, are currently available 6 .
Databáze: OpenAIRE
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