Plasmapheresis Followed by Intravenous Immunoglobulin in Presensitized Patients Awaiting Thoracic Organ Transplantation
| Autor: | Edward R. Garrity, R.M. Radvany, John A. Robinson, Martin G. Mullen |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Histocompatibility Testing Organ transplantation Humans Medicine Lung transplantation Heart transplantation biology business.industry Panel reactive antibody Immunoglobulins Intravenous Plasmapheresis General Medicine Middle Aged Surgery Transplantation biology.protein Heart Transplantation Female Lymphocyte Culture Test Mixed Antibody business Lung Transplantation |
| Zdroj: | Therapeutic Apheresis. 1:147-151 |
| ISSN: | 1091-6660 |
| DOI: | 10.1111/j.1744-9987.1997.tb00030.x |
| Popis: | Four highly sensitized patients awaiting thoracic organ transplantation were treated immediately preceding transplantation with 1 plasmapheresis and infusion of high dose intravenous immunoglobulin (IVIG). All 4 underwent successful surgery and have had minor to no rejection episodes over a range from 5 1/2 to 12 months. All panel reactive antibodies (PRA) were dithiotheitol (DTT) resistant, and 1 patient had IgG specific alloantibodies to a donor alloantigen. All 4 patients had positive donor cross matches prior to transplantation, and 3 of the 4 patients remained PRA negative for up to 9 months after allografting. Possible mechanisms of this therapy include inhibition of proliferating alloreactive B cells or suppression by antiidiotypic antibodies. Further study is warranted. |
| Databáze: | OpenAIRE |
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