Relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetic patients (JDDM38)

Autor: Azuma, Kanatsuka, Yasunori, Sato, Koichi, Kawai, Koichi, Hirao, Masashi, Kobayashi, Atsunori, Kashiwagi, Nobuyuki, Abe, Keiko, Arai, Hiroshi, Fujiya, Yoshihide, Fukumoto, Fumihiko, Dake, Tomohiro, Iizumi, Masaaki, Ito, Koichi, Iwasaki, Akira, Kanamori, Sumio, Kato, Masakazu, Kato, Akira, Kawara, Kenichi, Kimura, Kazumasa, Chikamori, Kotaro, Iemitsu, Shigetake, Kou, Mikihiko, Kudo, Yoshio, Kurihara, Gendai, Lee, Akira, Tsuruoka, Naoki, Manda, Kiyokazu, Matoba, Hiroshi, Hayashi, Masae, Minami, Nobuichi, Kuribayashi, Kazuhiro, Miyazawa, Yasuko, Chiba, Takeshi, Osonoi, Shin, Nakamura, Hideo, Sasaki, Katsutoshi, Komori, Mariko, Oishi, Akira, Okada, Fuminobu, Okuguchi, Morifumi, Yanagisawa, Hidekatsu, Sugimoto, Hiromichi, Sugiyama, Masahiko, Takai, Masato, Takaki, Hiroshi, Takamura, Hiroshi, Takeda, Kokichi, Tanaka, Takashi, Miwa, Osamu, Tomonaga, Madoka, Taguchi, Katsuya, Yamazaki, Takako, Wada, Noriharu, Yagi, Kuniko, Yamaoka, Atsuyoshi, Yuhara
Rok vydání: 2015
Předmět:
Male
medicine.medical_specialty
endocrine system diseases
medicine.drug_class
Endocrinology
Diabetes and Metabolism
Administration
Oral
030209 endocrinology & metabolism
Pharmacology
Body Mass Index
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Internal medicine
Type 2 diabetes mellitus
Internal Medicine
medicine
Humans
Hypoglycemic Agents
Oral antidiabetic drug
030212 general & internal medicine
Propensity Score
Aged
Glycemic
Glycated Hemoglobin
Dipeptidyl-Peptidase IV Inhibitors
business.industry
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
Articles
General Medicine
Middle Aged
medicine.disease
Sulfonylurea
Metformin
Sulfonylurea Compounds
Treatment Outcome
Clinical Science and Care
Diabetes Mellitus
Type 2
Propensity score‐matched cohort study
Propensity score matching
Female
Original Article
business
Body mass index
medicine.drug
Cohort study
Zdroj: Journal of Diabetes Investigation
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.12430
Popis: Aims/Introduction We carried out an observational cohort study to examine the relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetics. Materials and Methods We analyzed the CoDiC® database of the Japan Diabetes Data Management Study Group across 67 institutions in Japan. In a total of 3,698 drug‐naïve patients who were initiated with metformin, dipeptidyl peptidase‐4 inhibitor (DPP‐4i) or sulfonylurea (SU) from 2007 to 2012, we evaluated body mass index (BMI) and hemoglobin A1c (HbA1c). The patients were stratified according to their clinical features, and matched using a propensity score to adjust for baseline factors. Results HbA1c was reduced with all drugs, with the largest effect elicited by DPP‐4i and the smallest by SU (P = 0.00). HbA1c increased with SU after 6 months in the patients stratified by an age‐of‐onset of 25 (P = 0.00). The reduction in HbA1c was larger in patients with HbA1c of ≥8%, compared with that in patients with HbA1c of
Databáze: OpenAIRE
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