Risk Factors Associated with Recurrent Clostridioides difficile Infection
| Autor: | Nicoleta Negrut, Delia Carmen Nistor-Cseppento, Marius Rus, Tapan Behl, Simona Bungau, Cristiana Bustea, Delia Mirela Tit, Shamim Ahmad Khan, Cosmin Mihai Vesa, Flavia-Maria Pavel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Leadership and Management recurrent disease lcsh:Medicine Health Informatics Disease Clostridioides difficile Article 03 medical and health sciences 0302 clinical medicine Health Information Management Quality of life Internal medicine ATLAS score medicine Dementia risk factors 030212 general & internal medicine Risk factor First episode 0303 health sciences 030306 microbiology business.industry Health Policy lcsh:R Odds ratio medicine.disease Confidence interval antibiotic-associated diarrhea Antibiotic-associated diarrhea business Charlson Comorbidity Index |
| Zdroj: | Healthcare Healthcare, Vol 8, Iss 352, p 352 (2020) Volume 8 Issue 3 |
| ISSN: | 2227-9032 |
| Popis: | Clostridioides difficile (CD) is responsible for nosocomial diarrhea syndrome with possible severe progression. Recurrence of the disease induces higher health system costs, as well as exposes patients to additional health risks. Patients with recurrence of this disease are difficult to identify, so the purpose of this study is to quantify various demographic, clinical, and treatment factors that could prevent further progression to recurrence of the disease. In the period 2018&ndash 2019, about 195 patients were diagnosed with more than one episode of CDI in the three months following the first episode. The recurrence rate for CDI was 53.84% (60.95% for one episode and 39.05% for multiple episodes). Most commonly afflicted were 60&ndash 69-year-old patients, or those with higher Charlson Comorbidity Index (CCI). Multiple analyses associated cardiovascular (odds ratios (OR) = 3.02, 95% confidence intervals (CI) = 1.23&ndash 7.39, p = 0.015), digestive (OR = 3.58, 95% CI = 1.01&ndash 12.63, p = 0.047), dementia (OR = 3.26, 95% CI = 1.26&ndash 8.41, p = 0.014), immunosuppressive (OR = 3.88, 95% CI = 1.34&ndash 11.21, p = 0.012) comorbidities with recurrences. Risk factor identification in the first episode of CDI could lead to the implementation of treatment strategies to improve the patients&rsquo quality of life affected by this disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|