Assessment of the impacts of glyphosate and its commercial formulation Roundup® on the respiratory tree of the sea cucumber Holothuria forskali using a multivariate biomarker approach
| Autor: | Tarek Hajji, Khaoula Telahigue, Nejla Soudani, Wafa Trabelsi, Imen Rabeh, Chaima Fouzai, Mhamed El Cafsi, Salwa Nechi, Emna Chelbi |
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| Rok vydání: | 2020 |
| Předmět: |
Environmental Engineering
Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Sea Cucumbers 0208 environmental biotechnology Glycine 02 engineering and technology 010501 environmental sciences 01 natural sciences Trees chemistry.chemical_compound medicine Environmental Chemistry Animals Holothuria Food science 0105 earth and related environmental sciences chemistry.chemical_classification biology Holothuria forskali Chemistry Herbicides Glutathione peroxidase Public Health Environmental and Occupational Health Fatty acid General Medicine General Chemistry Glutathione Hydrogen Peroxide biology.organism_classification Malondialdehyde Ascorbic acid Pollution 020801 environmental engineering Catalase biology.protein Biomarkers |
| Zdroj: | Chemosphere. 269 |
| ISSN: | 1879-1298 |
| Popis: | In this study, the potential hazardous impacts of the technical grade glyphosate acid (GLY) and its commercial formulation roundup (RD®) were evaluated for the first time on holothurians. To do this, redox status, fatty acid (FA) profile, and histopathology aspects were assessed in the respiratory tree tissue of the sea cucumber Holothuria forskali following short-term exposure (96 h) to a series of concentrations (10, 100 and 1000 μg L−1) of GLY and RD® (glyphosate acid equivalent). Our results showed that both GLY and RD® promoted oxidative stress highlighted with an increase of hydrogen peroxide (H2O2), malondialdehyde (MDA), lipid peroxides (LOOH) and advanced oxidation protein product (AOPP) levels in all treated groups. In addition, both glyphosate forms were found to perturb the FA composition. However, changes in saturated (SFA) and polyunsaturated (PUFA) including some essential FA (LA, ARA, EPA and DHA) revealed differential compensatory/adaptive processes in H. forskali depending on the treatment. GLY and RD® were also found to modulate the enzymatic (glutathione S-transferases, glutathione peroxidase and catalase) and non-enzymatic (reduced glutathione and ascorbic acid) antioxidant defense status. Taken together, our results revealed that the commercial formulation produced more pronounced effects on H. forskali respiratory tree than the pure form. This finding was further confirmed by the histological observations. |
| Databáze: | OpenAIRE |
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