Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain
| Autor: | Aaron A. Salas-Sanchez, Haifa Othman, Mohamed Ammari, E. Lopez-Martin, Francisco J. Ares-Pena, Hafedh Abdelmelek, Alberto López-Furelos, Jose Manuel Leiro-Vidal, Mohsen Sakly |
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| Přispěvatelé: | Universidade de Santiago de Compostela. Departamento de Ciencias Morfolóxicas, Universidade de Santiago de Compostela. Departamento de Física Aplicada, Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía, Universidade de Santiago de Compostela. Instituto Interdisciplinar de Tecnoloxías Ambientais (CRETUS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nervous system
Hippocampus Glucocorticoid receptor Somatosensory system Rats Sprague-Dawley glucocorticoid receptor Biology (General) Spectroscopy HSP-70 Glial fibrillary acidic protein biology Chemistry Cerebrum GFAP General Medicine Computer Science Applications medicine.anatomical_structure Hypothalamus Female medicine.medical_specialty QH301-705.5 Catalysis Article Inorganic Chemistry Receptors Glucocorticoid Internal medicine Glial Fibrillary Acidic Protein medicine Animals HSP70 Heat-Shock Proteins Nonionizing radiation Physical and Theoretical Chemistry nonionizing radiation Molecular Biology QD1-999 Organic Chemistry Somatosensory Cortex Hsp70 Rats Endocrinology Gene Expression Regulation nervous system 2.45 GHz radiation biology.protein Biomarkers |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 5103, p 5103 (2021) International Journal of Molecular Sciences Volume 22 Issue 10 Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela Universidad de Santiago de Compostela (USC) |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Brain tissue may be especially sensitive to electromagnetic phenomena provoking signs of neural stress in cerebral activity. Fifty-four adult female Sprague-Dawley rats underwent ELISA and immunohistochemistry testing of four relevant anatomical areas of the cerebrum to measure biomarkers indicating induction of heat shock protein 70 (HSP-70), glucocorticoid receptors (GCR) or glial fibrillary acidic protein (GFAP) after single or repeated exposure to 2.45 GHz radiation in the experimental set-up. Neither radiation regime caused tissue heating, so thermal effects can be ruled out. A progressive decrease in GCR and HSP-70 was observed after acute or repeated irradiation in the somatosensory cortex, hypothalamus and hippocampus. In the limbic cortex however, values for both biomarkers were significantly higher after repeated exposure to irradiation when compared to control animals. GFAP values in brain tissue after irradiation were not significantly different or were even lower than those of nonirradiated animals in all brain regions studied. Our results suggest that repeated exposure to 2.45 GHz elicited GCR/HSP-70 dysregulation in the brain, triggering a state of stress that could decrease tissue anti-inflammatory action without favoring glial proliferation and make the nervous system more vulnerable. |
| Databáze: | OpenAIRE |
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