Genetic control of an epigenetic cell degeneration syndrome in Podospora anserina
| Autor: | Philippe Silar, Vicki Haedens, Fabienne Malagnac |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Genetics
MAP kinase kinase kinase Mutant Genes Fungal NADPH Oxidases Biology biology.organism_classification MAP Kinase Kinase Kinases Microbiology Adaptation Physiological Hedgehog signaling pathway Podospora anserina Sexual reproduction Epigenesis Genetic Fungal Proteins Podospora Protein Biosynthesis Mutation Morphogenesis Epigenetics Signal transduction Gene Signal Transduction |
| Zdroj: | Fungal genetics and biology : FGB. 42(6) |
| ISSN: | 1087-1845 |
| Popis: | Filamentous fungi frequently present degenerative processes, whose molecular basis is very often unknown. Here, we present three mutant screens that result in the identification of 29 genes that directly or indirectly control Crippled Growth (CG), an epigenetic cell degeneration of the filamentous ascomycete Podospora anserina. Two of these genes were previously shown to encode a MAP kinase kinase kinase and an NADPH oxidase involved in a signal transduction cascade that participates in stationary phase differentiations, fruiting body development and defence against fungal competitors. The numerous genes identified can be incorporated in a model in which CG results from the sustained activation of the MAP kinase cascade. Our data also emphasize the complex regulatory network underlying three interconnected processes in P. anserina: sexual reproduction, defence against competitors, and cell degeneration. |
| Databáze: | OpenAIRE |
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