Cerebral Cavernous Malformations Arise Independent of the Heart of Glass Receptor
| Autor: | Florence Riant, Mark L. Kahn, Xiangjian Zheng, Elisabeth Tournier-Lasserve, Cynthia D. Myers, Jisheng Yang, Benjamin Kleaveland, Wei Pan, Françoise Bergametti, Alan T. Tang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Hemangioma
Cavernous Central Nervous System medicine.medical_specialty Endothelium Mice Transgenic Article Retina Mice Fetus Proto-Oncogene Proteins Internal medicine medicine Animals Humans Receptor KRIT1 Protein Gene Advanced and Specialized Nursing business.industry Microfilament Proteins Brain Membrane Proteins Embryo medicine.anatomical_structure Endocrinology Membrane protein Neurology (clinical) Signal transduction Apoptosis Regulatory Proteins Carrier Proteins Cardiology and Cardiovascular Medicine business Microtubule-Associated Proteins |
| Zdroj: | Stroke. 45:1505-1509 |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | Background and Purpose— The Heart of Glass (HEG) receptor binds KRIT1 and functions with KRIT1, CCM2, and PDCD10 in a common signaling pathway required for heart and vascular development. Mutations in KRIT1, CCM2 , and PDCD10 also underlie human cerebral cavernous malformation (CCM) and postnatal loss of these genes in the mouse endothelium results in rapid CCM formation. Here, we test the role of HEG in CCM formation in mice and in humans. Methods— We constitutively or conditionally deleted Heg and Ccm2 genes in genetically modified mice. Mouse embryos, brain, and retina tissues were analyzed to assess CCM lesion formation. Results— In postnatal mice, CCMs form with Ccm2 −/− but not with Heg −/− or Heg −/− ; Ccm2 +/- endothelial cells. Consistent with these findings, human patients with CCM who lack exonic mutations in KRIT1, CCM2 , or PDCD10 do not have mutations in HEG . Conclusions— These findings suggest that the HEG-CCM signaling functions during cardiovascular development and growth, whereas CCMs arise because of loss of HEG-independent CCM signaling in the endothelium of the central nervous system after birth. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|