Herbal Active Ingredients: Potential for the Prevention and Treatment of Acute Lung Injury
| Autor: | Yue-Guo Wu, Chun-Xiao Gao, Chen-Huan Yu, Huan-Huan Zhang, Wen-Ying Yu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Membrane permeability Acute Lung Injury Phytochemicals Review Article Lung injury General Biochemistry Genetics and Molecular Biology Hypoxemia Edema Humans Medicine Respiratory system Intensive care medicine Diffuse alveolar damage Aspirin General Immunology and Microbiology business.industry Mortality rate General Medicine respiratory system respiratory tract diseases medicine.symptom business medicine.drug |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2021 (2021) |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2021/5543185 |
| Popis: | Acute lung injury (ALI) is a life-threatening clinical syndrome with high morbidity and mortality. The main pathological features of ALI are increased alveolar-capillary membrane permeability, edema, uncontrolled migration of neutrophils to the lungs, and diffuse alveolar damage, resulting in acute hypoxemic respiratory failure. Glucocorticoids, aspirin, and other anti-inflammatory drugs are commonly used to treat ALI. Respiratory supports, such as a ventilator, are used to alleviate hypoxemia. Many treatment methods are available, but they cannot significantly ameliorate the quality of life of patients with ALI and reduce mortality rates. Herbal active ingredients, such as flavonoids, terpenoids, saponins, alkaloids, and quinonoids, exhibit advantages for ALI prevention and treatment, but the underlying mechanism needs further study. This paper summarizes the role of herbal active ingredients in anti-ALI therapy and progresses in the understanding of their mechanisms. The work also provides some references and insights for the discovery and development of novel drugs for ALI prevention and treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |