68Ga-Prostate-specific membrane antigen (PSMA) positron emission tomography (pet) in prostate cancer: a systematic review and meta-analysis
| Autor: | Stefano Fanti, Matteo Bardisserotto, George B Coura-Filho, Diego B Piant, Fabio Peroba Esteves, Bruna Macedo, Bruno Hochhegger, Ana Maria Marques da Silva, Gustavo do Vale Gomes, Cinthia Scatolin Tem-Pass, Ana Emília Brito, Eduardo Mundstock, Wanderley Marques Bernardo, Cristina Sebastião Matushita, Diego H. Roman, Phelipi Nunes Schuck, Juliano Julio Cerci, Jonatas L Pereira, Bárbara Juarez Amorim |
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| Přispěvatelé: | Matushita CS, da Silva AMM, Schuck PN, Bardisserotto M, Piant DB, Pereira JL, Cerci JJ, Coura-Filho GB, Esteves FP, Amorim BJ, Gomes GV, Brito AET, Bernardo WM, Mundstock E, Fanti S, Macedo B, Roman DH, Tem-Pass CS, Hochhegger B. |
| Rok vydání: | 2021 |
| Předmět: |
Male
Biochemical recurrence Oncology medicine.medical_specialty Urology medicine.medical_treatment 030232 urology & nephrology Review Article Glu-NH-CO-NH-Lys-(Ahx)-((68)Ga(HBED-CC)) [Supplementary Concept] Cochrane Library 03 medical and health sciences Prostate cancer 0302 clinical medicine Internal medicine medicine Humans familial [Supplementary Concept] medicine.diagnostic_test Prostate cancer 68Ga Prostatectomy business.industry Prostatic Neoplasms Cancer medicine.disease Diseases of the genitourinary system. Urology Radiation therapy (225)Ac-PSMA-617 [Supplementary Concept] Positron emission tomography Positron-Emission Tomography 030220 oncology & carcinogenesis Meta-analysis RC870-923 Tomography X-Ray Computed business |
| Zdroj: | International Brazilian Journal of Urology, Vol 47, Iss 4, Pp 705-729 (2021) International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology International braz j urol, Volume: 47, Issue: 4, Pages: 705-729, Published: 30 JUL 2021 International braz j urol v.47 n.4 2021 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU |
| ISSN: | 1677-6119 1677-5538 |
| DOI: | 10.1590/s1677-5538.ibju.2019.0817 |
| Popis: | Introduction: Prostate cancer (PC) is the second most commonly diagnosed cancer in males. 68Ga-PSMA PET/CT, a non-invasive diagnostic tool to evaluate PC with prostate-specific membrane antigen (PSMA) expression, has emerged as a more accurate alternative to assess disease staging. We aimed to identify predictors of positive 68Ga-PSMA PET and the accuracy of this technique. Materials and methods: Diagnostic accuracy cross-sectional study with prospective and retrospective approaches. We performed a comprehensive literature search on PubMed, Cochrane Library, and Embase database in search of studies including PC patients submitted to radical prostatectomy or radiotherapy with curative intent and presented biochemical recurrence following ASTRO 1996 criteria. A total of 35 studies involving 3910 patients submitted to 68-Ga-PSMA PET were included and independently assessed by two authors: 8 studies on diagnosis, four on staging, and 23 studies on restaging purposes. The significance level was α=0.05. Results: pooled sensitivity and specificity were 0.90 (0.86-0.93) and 0.90 (0.82-0.96), respectively, for diagnostic purposes; as for staging, pooled sensitivity and specificity were 0.93 (0.86-0.98) and 0.96 (0.92-0.99), respectively. In the restaging scenario, pooled sensitivity and specificity were 0.76 (0.74-0.78) and 0.45 (0.27-0.58), respectively, considering the identification of prostate cancer in each described situation. We also obtained specificity and sensitivity results for PSA subdivisions. Conclusion: 68Ga-PSMA PET provides higher sensitivity and specificity than traditional imaging for prostate cancer. |
| Databáze: | OpenAIRE |
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