A Subgroup of Patients With Hospital-acquired Pneumonia Do Not Require Broad-spectrum Gram-negative Antimicrobial Coverage
| Autor: | Eilidh Farquhar, Dominic P Dee, Claire L. Mackintosh, Alba Saenz de Villaverde, I.F. Laurenson, Muge Cevik, Morgan H Evans, Ed Whittaker, Clark D Russell |
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| Přispěvatelé: | University of St Andrews. School of Medicine, University of St Andrews. Infection and Global Health Division |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
RM medicine.medical_specialty education Antimicrobial stewardship gentamicin Hospital-acquired pneumonia Tachypnea 3rd-NDAS law.invention SDG 3 - Good Health and Well-being stomatognathic system Anti-Infective Agents RA0421 law RA0421 Public health. Hygiene. Preventive Medicine Internal medicine Severity of illness medicine hospital-acquired pneumonia Humans Online Only Articles Gentamicin Doxycycline Cross Infection doxycycline business.industry Healthcare-Associated Pneumonia QR Microbiology Pneumonia medicine.disease Intensive care unit Neutrophilia Hospitals RM Therapeutics. Pharmacology QR Anti-Bacterial Agents Systemic inflammatory response syndrome antimicrobial stewardship Infectious Diseases AcademicSubjects/MED00290 Gram-negative bacteria Brief Reports medicine.symptom business medicine.drug |
| Zdroj: | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America Russell, C D, Whittaker, E, Dee, D P, Farquhar, E, Saenz de Villaverde, A, Evans, M H, Laurenson, I F, Mackintosh, C L & Cevik, M 2020, ' A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum gram-negative antimicrobial coverage ', Clinical Infectious Diseases . https://doi.org/10.1093/cid/ciaa391 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | C.D.R. is supported by an Edinburgh Clinical Academic Track (ECAT)/Wellcome Trust PhD Training Fellowship for Clinicians award (214178/Z/18/Z). Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and the absence of diabetes mellitus and prior doxycycline treatment (but not the time to HAP onset) identified patients not requiring broad-spectrum Gram-negative coverage. Publisher PDF |
| Databáze: | OpenAIRE |
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