Human neutrophil peptide in lung chronic allograft dysfunction

Autor:	Cavan S. Reilly, Tereza Cervenka, Chris H. Wendt, Marshall I. Hertz, Trisha Becker
Rok vydání:	2011
Předmět:	Graft Rejection Human neutrophil Neutrophils Health Toxicology and Mutagenesis Clinical Biochemistry Bronchiolitis obliterans Context (language use) Peptide Enzyme-Linked Immunosorbent Assay Biochemistry Article Pulmonary function testing Medicine Humans Prospective Studies chemistry.chemical_classification Lung medicine.diagnostic_test business.industry medicine.disease humanities Bronchoalveolar lavage medicine.anatomical_structure chemistry Immunology Biomarker (medicine) business Peptides Bronchoalveolar Lavage Fluid Biomarkers Lung Transplantation
Zdroj:	Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 16(8)
ISSN:	1366-5804
Popis:	Context: Our previous case-control study identified human neutrophil peptide (HNP) as a potential biomarker for bronchiolitis obliterans syndrome (BOS) in lung transplant recipients.Objective: To prospectively validate HNP as a biomarker for BOS.Materials and methods: HNP was measured by ELISA in bronchoalveolar lavage (BAL) fluid in lung transplant recipients.Results: The first HNP measurement after reaching baseline pulmonary function was predictive of developing BOS ≥2 (p = 0.0419). HNP remained elevated in those that developed BOS. The effect of potential confounders did not significantly impact BOS-free survival time.Conclusion: HNP levels are elevated early and persistently in those that develop BOS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab052104738d4f5b7305f8a848b66615 https://pubmed.ncbi.nlm.nih.gov/21988113 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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