Evaluation of histophysiological alterations associated with ketoprofen administration in albino NMRI mice
| Autor: | Monica Marilena Tantu, Magdalena Diaconu, Irina Fierascu, Cristina Florentina Plesa, Cristina Maria Ponepal, Camelia Nicolae, Radu Claudiu Fierascu, Magdalena Cristina Zagardan, Cristina Liliana Soare, Roxana Maria Nemes, Alina Paunescu, Alina Bisoc |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Ketoprofen medicine.medical_specialty Necrosis 040301 veterinary sciences 010501 environmental sciences Body weight 01 natural sciences 0403 veterinary science Mice chemistry.chemical_compound Internal medicine Animals Medicine 0105 earth and related environmental sciences Pharmacology Triglyceride Cholesterol business.industry Blood biochemistry 04 agricultural and veterinary sciences General Medicine Endocrinology Liver chemistry Nmri mice Hemoglobin Chemical and Drug Induced Liver Injury medicine.symptom business medicine.drug |
| Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 393:1033-1039 |
| ISSN: | 1432-1912 0028-1298 |
| Popis: | The aim of this study was to investigate the changes caused by the administration of ketoprofen to albino NMRI mice on some hematological, biochemical, and structural parameters. For this purpose, the mice were divided into two lots: a control batch and an experimental batch to which ketoprofen was administered subcutaneously at a dose of 10 mg/kg body weight per day for 7 days. A decrease in erythrocyte number and hemoglobin was observed altogether with the increase in white blood cells. Blood biochemistry indicates increased blood glucose, cholesterol, and triglyceride levels. Enzyme values (AST, ALT, and ALP) show a significant increase. Hepatic pathology reveals the enlargement of sinusoidal capillaries, the presence of leukocyte infiltrates associated with necrosis zones. |
| Databáze: | OpenAIRE |
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