Avian blood parasite richness decreases with major histocompatibility complex class I loci number
| Autor: | Mathieu Giraudeau, Orsolya Vincze, Claire Loiseau |
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| Přispěvatelé: | Hungarian Department of Biology and Ecology [Cluj‑Napoca, Romania], Babes-Bolyai University [Cluj-Napoca] (UBB), James Cook University (JCU), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), LIttoral ENvironnement et Sociétés - UMRi 7266 (LIENSs), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS), LIttoral ENvironnement et Sociétés (LIENSs), La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
[SDV]Life Sciences [q-bio] Vertebrate genome Major histocompatibility complex 010603 evolutionary biology 01 natural sciences Birds Major Histocompatibility Complex 03 medical and health sciences Animals Parasites Copy-number variation Blood parasites Allele Gene 030304 developmental biology Evolutionary Biology 0303 health sciences biology Genetic Variation Haemosporida Agricultural and Biological Sciences (miscellaneous) Evolutionary biology biology.protein Species richness General Agricultural and Biological Sciences human activities |
| Zdroj: | Biology Letters Biology Letters, Royal Society, The, 2021, 17 (8), ⟨10.1098/rsbl.2021.0253⟩ Biol Lett Biology Letters, 2021, 17 (8), ⟨10.1098/rsbl.2021.0253⟩ |
| ISSN: | 1744-957X 1744-9561 |
| DOI: | 10.1098/rsbl.2021.0253 |
| Popis: | Major histocompatibility complex (MHC) genes are among the most polymorphic in the vertebrate genome. The high allele diversity is believed to be maintained primarily by sexual and pathogen-mediated balancing selection. The number of MHC loci also varies greatly across vertebrates, most notably across birds. MHC proteins play key roles in presenting antigens on the cell surface for recognition by T cells, with class I proteins specifically targeting intracellular pathogens. Here, we explore the hypothesis that MHC class I diversity (measured as loci number) coevolves with haemosporidian parasite burden of the host. Using data on 54 bird species, we demonstrate that high-MHC class I diversity is associated with significantly lower richness of Plasmodium , Haemoproteus as well as overall haemosporidian parasite lineages, the former thus indicating more efficient protection against intracellular pathogens. Nonetheless, the latter associations were only detected when MHC diversity was assessed using cloning and not 454 pyrosequencing-based studies, nor across all genotyping methods combined. Our results indicate that high-MHC class I diversity might play a key role in providing qualitative resistance against diverse haemosporidian parasites in birds, but further clarification is needed for the origin of contrasting results when using different genotyping methods for MHC loci quantification. |
| Databáze: | OpenAIRE |
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