Quinoline alkaloids from Acronychia laurifolia
| Autor: | Bjarne Gram Hansen, Djaja D. Soejarto, Domingo A. Madulid, Geoffrey A. Cordell, Yumi Dong, Heebyung Chai, A. D. Kinghorn, John M. Pezzuto, F.D. Horgen, Baoliang Cui, Norman R. Farnsworth |
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| Rok vydání: | 1999 |
| Předmět: |
Stereochemistry
Plant Science Horticulture Biochemistry Acronychia chemistry.chemical_compound Alkaloids Tumor Cells Cultured Sesamolin Humans heterocyclic compounds Molecular Biology biology Spectrum Analysis Alkaloid Quinoline Biological activity General Medicine Plants biology.organism_classification Antineoplastic Agents Phytogenic Human tumor Rutaceae chemistry Kokusaginine Quinolines Drug Screening Assays Antitumor |
| Zdroj: | Phytochemistry. 52:95-98 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/s0031-9422(99)00039-4 |
| Popis: | Bioassay-directed fractionation of a root extract of Acronychia laurifolia (Rutaceae) using the KB-V1+ human tumor cell line led to the isolation of six quinoline alkaloids. One of these alkaloids is novel, namely, 2,3-methylenedioxy-4,7-dimethoxyquinoline and the other five were identified as the known compounds, evolitrine, gamma-fagarine, skimmianine, kokusaginine and maculosidine. Two known bis-tetrahydrofuran lignans, sesamolin and yangambin, were also identified. The structure of the new alkaloid was determined by spectroscopic methods. All of the isolates were evaluated against a panel of human cancer cell lines; four of the alkaloids showed weak cytotoxic activity. |
| Databáze: | OpenAIRE |
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