Safety assessment of MEFAS: an innovative hybrid salt of mefloquine and artesunate for malaria treatment

Autor: Francislaine Aparecida dos Reis Lívero, Fabiane Antiquera Ferreira, Paulo Roberto Dalsenter, Nubia Boechat, Daniely Alves de Lima, Karoline Bach Pauli, Gustavo Ratti da Silva, Rita de Cássia Lima Ribeiro, Carlos Eduardo Linhares Andreotti, Arquimedes Gasparotto Junior, Emerson Luiz Botelho Lourenço
Rok vydání: 2019
Předmět:
Zdroj: Drug and chemical toxicology. 44(4)
ISSN: 1525-6014
Popis: Malaria is a global public health problem that causes approximately 445 000 deaths annually worldwide, especially in underdeveloped countries. Because of the high prevalence and mortality of the disease, new and less toxic therapeutic agents need to be developed, such as MEFAS, a low-cost hybrid salt that consists of artesunate and mefloquine. However, the efficacy of MEFAS has been systematically demonstrated, its safety requires further investigation. This study investigated the acute toxicity of MEFAS and its precursors, artesunate, and mefloquine. A total of 42 female Swiss mice were divided into seven groups (
Databáze: OpenAIRE