α2-Adrenergic Agonist Clonidine for Improving Spatial Working Memory in Parkinson's Disease
| Autor: | Paavo Riekkinen, Minna Riekkinen |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Agonist Parkinson's disease medicine.drug_class Blood Pressure Neuropsychological Tests Spatial memory Clonidine Heart Rate Memory Adrenergic alpha-2 Receptor Agonists medicine Humans Hypnotics and Sedatives Pharmacology (medical) Recognition memory Working memory Memoria Parkinson Disease Cognition medicine.disease Psychiatry and Mental health Memory Short-Term Space Perception Anesthesia Female Psychology Adrenergic alpha-Agonists Neuroscience medicine.drug |
| Zdroj: | Journal of Clinical Psychopharmacology. 19:444-449 |
| ISSN: | 0271-0749 |
| DOI: | 10.1097/00004714-199910000-00008 |
| Popis: | The loss of dopaminergic cells during Parkinson's disease (PD) produces "frontal"-like impairment in spatial working memory (SWM) and planning functions. This study investigated whether an alpha2-adrenergic agonist, clonidine (0.5 or 2 microg/kg, orally), improves SWM, spatial short-term or spatial recognition memory, and planning functions in PD patients. Clonidine 2 microg/kg decreased errors in SWM, but a lower dose, 0.5 microg/kg, had no effect on performance. Clonidine 0.5 and 2 microg/kg failed to improve the strategy used to solve the SWM test. Clonidine 0.5 and 2 microg/kg had no effect on accuracy of performance in the other tests. These results showed that clonidine improves performance in a test of SWM and that this is not due to improved spatial short-term or spatial recognition memory or planning functions. The authors suggest that stimulation of alpha2-adrenoceptors improves the mnemonic processing required for accurate SWM performance in PD patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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