Pharmacokinetics and bioequivalence evaluation of two fixed-dose tablet formulations of dihydroartemisinin and piperaquine in Vietnamese subjects
| Autor: | Bui Dai, Nguyen Xuan Thanh, Michael D. Edstein, Jason P. Geue, Thomas Travers, Nguyen Trong Chinh, R. S. Addison, Nguyen Ngoc Quang |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Vietnamese medicine.medical_treatment Chemistry Pharmaceutical Dihydroartemisinin Bioequivalence Pharmacology Dosage form Antimalarials Pharmacokinetics Tandem Mass Spectrometry Piperaquine parasitic diseases medicine Humans Pharmacology (medical) Artemisinin Cross-Over Studies business.industry Crossover study language.human_language Artemisinins Drug Combinations Infectious Diseases Therapeutic Equivalency Area Under Curve language Quinolines business medicine.drug Chromatography Liquid Half-Life |
| Zdroj: | Antimicrobial agents and chemotherapy. 53(2) |
| ISSN: | 1098-6596 |
| Popis: | The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were only marginally different between the two formulations, similar therapeutic efficacies are expected in the treatment of malaria infections. |
| Databáze: | OpenAIRE |
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