Risk Factors of Streptococcus suis Infection in Vietnam. A Case-Control Study
| Autor: | Nghia, HD, Ho, DT, Tu, LETP, Le, TP, Wolbers, M, Thai, CQ, Cao, QT, Hoang, NV, Nguyen, VM, Nga, TV, Tran, VT, Thao, LETP, Phu, NH, Nguyen, HP, Chau, TT, Tran, TH, Sinh, DX, Dinh, XS, Diep, TS, To, SD, Hang, HT, Hoang, TT, Truong, H, Campbell, J, Chau, NV, Nguyen, VV, Chinh, NT, Nguyen, TC, Dung, NV, Nguyen, VD, Hoa, NT, Ngo, TH, Spratt, BG, Hien, TT, Farrar, J, Schultsz, C |
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| Přispěvatelé: | Faculteit der Geneeskunde, AII - Amsterdam institute for Infection and Immunity, Infectious diseases |
| Rok vydání: | 2011 |
| Předmět: |
Bacterial Diseases
Male Veterinary medicine Non-Clinical Medicine Streptococcus suis Epidemiology MENINGITIS Sus scrofa lcsh:Medicine Disease Polymerase Chain Reaction Foodborne Diseases Infectious Diseases of the Nervous System Risk Factors Zoonoses lcsh:Science 0303 health sciences Multidisciplinary biology Zoonotic Diseases Zoonosis Middle Aged Hospitals 3. Good health PCR Infectious Diseases medicine.anatomical_structure Veterinary Diseases Vietnam Carrier State Science & Technology - Other Topics Medicine Female Bacterial and Foodborne Illness Meningitis Research Article Adult medicine.medical_specialty General Science & Technology Clinical Research Design Gastroenterology and Hepatology CHINA Infectious Disease Epidemiology 03 medical and health sciences Age Distribution Bacterial Meningitis Streptococcal Infections Internal medicine Throat MD Multidisciplinary medicine Animals Humans Biology 030304 developmental biology Science & Technology Health Care Policy Population Biology MULTIDISCIPLINARY SCIENCES 030306 microbiology business.industry lcsh:R Case-control study biology.organism_classification medicine.disease Carriage Case-Control Studies Multivariate Analysis Veterinary Science lcsh:Q HONG-KONG Health Statistics business |
| Zdroj: | PLoS ONE PLoS ONE, 6(3):e17604. Public Library of Science PLoS ONE, Vol 6, Iss 3, p e17604 (2011) PLoS ONE, 6(3). Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND: Streptococcus suis infection, an emerging zoonosis, is an increasing public health problem across South East Asia and the most common cause of acute bacterial meningitis in adults in Vietnam. Little is known of the risk factors underlying the disease. METHODS AND FINDINGS: A case-control study with appropriate hospital and matched community controls for each patient was conducted between May 2006 and June 2009. Potential risk factors were assessed using a standardized questionnaire and investigation of throat and rectal S. suis carriage in cases, controls and their pigs, using real-time PCR and culture of swab samples. We recruited 101 cases of S. suis meningitis, 303 hospital controls and 300 community controls. By multivariate analysis, risk factors identified for S. suis infection as compared to either control group included eating "high risk" dishes, including such dishes as undercooked pig blood and pig intestine (OR(1) = 2.22; 95%CI = [1.15-4.28] and OR(2) = 4.44; 95%CI = [2.15-9.15]), occupations related to pigs (OR(1) = 3.84; 95%CI = [1.32-11.11] and OR(2) = 5.52; 95%CI = [1.49-20.39]), and exposures to pigs or pork in the presence of skin injuries (OR(1) = 7.48; 95%CI = [1.97-28.44] and OR(2) = 15.96; 95%CI = [2.97-85.72]). S. suis specific DNA was detected in rectal and throat swabs of 6 patients and was cultured from 2 rectal samples, but was not detected in such samples of 1522 healthy individuals or patients without S. suis infection. CONCLUSIONS: This case control study, the largest prospective epidemiological assessment of this disease, has identified the most important risk factors associated with S. suis bacterial meningitis to be eating 'high risk' dishes popular in parts of Asia, occupational exposure to pigs and pig products, and preparation of pork in the presence of skin lesions. These risk factors can be addressed in public health campaigns aimed at preventing S. suis infection. |
| Databáze: | OpenAIRE |
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