Anandamide activation of CB1 receptors increases spontaneous bursting and oscillatory activity in the thalamus
| Autor: | Javier Cudeiro, Casto Rivadulla, Miguel Dasilva, Kenneth L. Grieve |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
AM251
Cannabinoid receptor Oscillations Polyunsaturated Alkamides Thalamus Central nervous system Arachidonic Acids Burst chemistry.chemical_compound Bursting Piperidines Receptor Cannabinoid CB1 medicine Animals Cannabinoid Receptor Antagonists Visual Cortex Cannabinoid Receptor Agonists Neurons Chemistry musculoskeletal neural and ocular physiology General Neuroscience Geniculate Bodies Electroencephalography Anandamide Endocannabinoid system Rats medicine.anatomical_structure nervous system Metabotropic glutamate receptor Pyrazoles lipids (amino acids peptides and proteins) Sleep Neuroscience psychological phenomena and processes medicine.drug Endocannabinoids |
| Zdroj: | RUC. Repositorio da Universidade da Coruña instname |
| Popis: | [Abstract] The endocannabinoid system is a modulatory system that has been strongly associated with the regulation of functions as learning and memory, pain perception and sensory physiology in many areas of the central nervous system. However, although a role in sensory processing has been demonstrated at the level of the thalamus, the influence of the endocannabinoid system on thalamic rhythms and oscillations has been less studied, despite the fact that such activities are significant characteristics of the thalamic state. The present work aimed to characterize the role of anandamide (AEA) – one of the endogenous CB1 receptor agonists – and AM251 – a CB1 antagonist – in the modulation of burst firing and oscillatory activity present in the dLGN of the anesthetized rat. Administration of AEA (0.5 mg/kg iv) increased the number of bursts in the majority of the cells tested and induced the appearance of a slow delta-like (1.5 Hz) oscillatory activity. These effects were CB1-mediated, as demonstrated by the complete antagonism during the co-application of AM251 (0.5 mg/kg iv). Thus, by demonstrating that the AEA-mediated activation of CB1 receptors increases spontaneous bursting and oscillatory activity in the thalamus our study infers that endocannabinoids could have a role in processes controlling the sleep–wake cycle and level of arousal. Ministerio de Ciencia e Innovación; BFU2009-08169 Xunta de Galicia; 2007/000140-0 |
| Databáze: | OpenAIRE |
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