Thoracic Manifestations of Primary Humoral Immunodeficiency: A Comprehensive Review
| Autor: | Xavier Buy, Guillaume Bierry, Afshin Gangi, M. Y. Jeung, Catherine Roy, Cindy Barnig, Julien Boileau, Bernard Gasser, Anne Sophie Korganow |
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| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Response to therapy Thoracic Diseases Humans Medicine Radiology Nuclear Medicine and imaging In patient Respiratory system Immunodeficiency Lung biology business.industry Immunologic Deficiency Syndromes medicine.disease Immunity Humoral medicine.anatomical_structure Immunology Primary immunodeficiency biology.protein Radiography Thoracic sense organs Antibody Tomography X-Ray Computed Airway business |
| Zdroj: | RadioGraphics. 29:1909-1920 |
| ISSN: | 1527-1323 0271-5333 |
| DOI: | 10.1148/rg.297095717 |
| Popis: | Humoral immunodeficiencies, which are characterized by defective production of antibodies, are the most common types of primary immunodeficiency. Pulmonary changes are present in as many as 60% of patients with humoral immunodeficiency. Chronic changes and recurrent infections in the respiratory airways are the main causes of morbidity and mortality in those affected by a humoral immunodeficiency. Medical imaging, especially computed tomography (CT), plays a crucial role in the initial detection and characterization of changes and in monitoring the response to therapy. The spectrum of abnormalities seen at thoracic imaging includes noninfectious airway disorders, infections, chronic lung diseases, chronic inflammatory conditions (granulomatosis, interstitial pneumonias), and benign and malignant neoplasms. Recognition of characteristic CT and radiographic features, and correlation of those features with clinical and laboratory findings, are necessary to differentiate between the many possible causes of parenchymal and mediastinal disease seen in patients with primary humoral immunodeficiencies. |
| Databáze: | OpenAIRE |
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