Altered clot microstructure detected in obstructive sleep apnoea hypopnoea syndrome
| Autor: | Simon J. Davidson, R. L. Williams, Karl Hawkins, Keith Morris, Maria Wilczynska, Sophia N. Stanford, Keir Lewis, Adrian Evans, Matthew Lawrence, Lindsay D’Silva |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pathology Neuroscience (miscellaneous) Medicine (miscellaneous) 030204 cardiovascular system & hematology Clot elasticity – G׳ 03 medical and health sciences Behavioral Neuroscience Sleep apnoea 0302 clinical medicine Full Length Article Internal medicine Medicine Platelet In patient Coagulation screening 030212 general & internal medicine Sleep study Morning Coagulation business.industry Clot microstructure Diurnal temperature variation medicine.disease Pathophysiology Gel time Cardiology business Fractal dimension Hypopnea |
| Zdroj: | Sleep Science |
| ISSN: | 1984-0063 |
| DOI: | 10.1016/j.slsci.2016.02.175 |
| Popis: | Abnormal clot microstructure plays a pivotal role in the pathophysiology of thromboembolic diseases. Assessing the viscoelastic properties of clot microstructure using novel parameters, Time to Gel Point (T GP ), Fractal Dimension (d f ) and clot elasticity (G׳ GP ) could explain the increased cardiovascular and thromboembolic events in patients with Obstructive Sleep Apnoea Hypopnea Syndrome (OSAHS). We wanted to compare T GP , d f , and G׳ GP and their diurnal variation in OSAHS and symptomatic comparators. thirty six patients attending a sleep disturbed breathing clinic with symptoms of OSAHS were recruited. T GP , d f and G׳ GP were measured alongside standard coagulation screening, thrombin generation assays, and platelet aggregometry at 16:00 h and immediately after an in-patient sleep study at 07:30 h. OSAHS group had significantly lower afternoon d f than comparators (1.705±0.033 vs. 1.731±0.031, p |
| Databáze: | OpenAIRE |
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