Effect of 1% sodium alendronate in the non-surgical treatment of periodontal intraosseous defects: a 6-month clinical trial

Autor: Luís Otávio Miranda Cota, Bernardo Carvalho Dutra, Fernando Oliveira Costa, Peterson Antônio Dutra Oliveira, Flávio Ricardo Manzi, Sheila Cavalca Cortelli, Alcione Maria Soares Dutra Oliveira
Přispěvatelé: COSTA, FERNANDO https://orcid.org/0000-0002-7687-1238
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Bone Regeneration
Time Factors
Dentistry
law.invention
Placebos
0302 clinical medicine
Scaling and root planing
Randomized controlled trial
law
Medicine
Biphosphonates
Alendronate
Bone Density Conservation Agents
Dental Plaque Index
Cone-Beam Computed Tomography
Middle Aged
Bone Diseases
Infectious
Treatment Outcome
030220 oncology & carcinogenesis
Female
medicine.symptom
Adult
medicine.medical_specialty
Periodontal examination
Bleeding on probing
Placebo
Statistics
Nonparametric
03 medical and health sciences
Dentistry
Oral Surgery & Medicine
Humans
Periodontal Probing
Periodontitis
General Dentistry
Dental scaling
business.industry
Sodium
Reproducibility of Results
alendronate
030206 dentistry
Original Articles
medicine.disease
Chronic periodontitis
Surgery
lcsh:RK1-715
lcsh:Dentistry
Chronic Periodontitis
business
Follow-Up Studies
Zdroj: Journal of Applied Oral Science
Journal of Applied Oral Science, Vol 25, Iss 3, Pp 310-317
Scielo
Repositório Institucional da UNITAU
Universidade de Taubaté (UNITAU)
instacron:UNITAU
Journal of Applied Oral Science, Volume: 25, Issue: 3, Pages: 310-317, Published: JUN 2017
Journal of Applied Oral Science v.25 n.3 2017
Journal of applied oral science
Universidade de São Paulo (USP)
instacron:USP
ISSN: 1678-7765
1678-7757
Popis: Made available in DSpace on 2019-09-11T20:51:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2017 Abstract Background and objectives Few studies have evaluated the effect of the topical application of sodium alendronate (ALN) on the treatment of intrabuccal bone defects, especially those caused by periodontitis. This 6-month randomized placebo controlled clinical trial aimed at evaluating the effect of non-surgical periodontal treatment associated with the use of 1% ALN, through clinical evaluations and cone-beam computed tomography (CBCT). Material and Methods Twenty individuals with chronic periodontitis underwent periodontal examination at the baseline as well as 3 and 6 months after periodontal treatment, registering clinical attachment level (CAL), periodontal probing depth (PPD), and bleeding on probing (BOP) as the clinical outcomes. After manual scaling and root planing, 40 bilateral sites with interproximal vertical bone defects were randomly treated with either 1% ALN gel or a placebo. Bone defects were evaluated through CBCT at the baseline and 6 months post-treatment. The clinical and CBCT parameters were compared using the Wilcoxon and Friedman tests (p
Databáze: OpenAIRE
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