‘Real-life experience’: recurrence rate at 3 years with Hexvix® photodynamic diagnosis-assisted TURBT compared with good quality white light TURBT in new NMIBC—a prospective controlled study
| Autor: | Kevin M Gallagher, Hannah Lee, Roland Donat, Paramananthan Mariappan, Claire H. Anderson, Kayleigh Gray, Sarah Stewart |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Nephrology medicine.medical_specialty Light Urology medicine.medical_treatment 030232 urology & nephrology Kaplan-Meier Estimate Cystectomy Risk Assessment 03 medical and health sciences 0302 clinical medicine Internal medicine Non-muscle invasive bladder cancer (NMIBC) Journal Article Humans Medicine Neoplasm Invasiveness Prospective Studies Prospective cohort study Aged Photosensitizing Agents Bladder cancer medicine.diagnostic_test business.industry Photodynamic diagnosis (PDD) Aminolevulinic Acid Cystoscopy medicine.disease Surgery Administration Intravesical Surgery Computer-Assisted Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Cohort Female Original Article Transurethral resection of bladder tumour (TURBT) Neoplasm Recurrence Local business Risk assessment Hexvix |
| Zdroj: | World Journal of Urology Gallagher, K M, Gray, K, Anderson, C H, Lee, H, Stewart, S, Donat, R & Mariappan, P 2017, ' 'Real-life experience' : recurrence rate at 3 years with Hexvix(®) photodynamic diagnosis-assisted TURBT compared with good quality white light TURBT in new NMIBC-a prospective controlled study ', World journal of urology, vol. 35, no. 12, 10.1007/s00345-017-2077-6, pp. 1871-1877 . https://doi.org/10.1007/s00345-017-2077-6 |
| ISSN: | 1433-8726 0724-4983 |
| DOI: | 10.1007/s00345-017-2077-6 |
| Popis: | Purpose To compare the recurrence rate at 3 years (RR-3y) for non-muscle invasive bladder cancer (NMIBC) between good quality (GQ) PDD-TURBT and GQWL-TURBT where PDD is used in routine practice for all new tumours. Methods All new, consecutive, NMIBC that received “good quality” criteria first TURBT across a university hospital service were prospectively recruited to this study over a 4-year period. Data were prospectively collected on all WL-TURBTs performed in 2007/8 and compared with PDD-TURBT from 2009/10. Only resection meeting strict “good quality criteria” were included from each cohort to control for resection quality, then cases were further matched 1:1 based on demographic and pathological criteria. The primary outcome was overall and risk group-specific recurrence rate at 3 years. Results Of 808 patients recruited, 345 had GQ-TURBT for NMIBC and were included. RR-3y was significantly less for GQ-PDD overall [RR-3y: GQ-PDD: 57/146 (39.0%), GQ-WL: 72/135 (53.3%) OR = 0.56 (0.35–0.90) p = 0.02] and on a 1:1 matched pair basis [RR GQ-PDD: 29/118 (24.6) vs. 59/118 (50.0) OR 0.33 (0.19–0.57) p |
| Databáze: | OpenAIRE |
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