AB3217-A, a novel anti-mite substance produced by a strain of Streptomyces platensis
| Autor: | Kenji Kanbe, Hikaru Nakamura, Sachiyo Yatagai, Atsushi Takahashi, Yasunori Sato, Tsuyoshi Tamamura, Yoichi Iitaka, Yayoi Mimura, Kiyoshi Sato, Hiroshi Naganawa, Tomio Takeuchi |
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| Rok vydání: | 1992 |
| Předmět: |
Microbiological Techniques
Insecticides Magnetic Resonance Spectroscopy Spectrophotometry Infrared Stereochemistry Amberlite Microbial Sensitivity Tests chemistry.chemical_compound Drug Discovery Animals Tetranychus urticae Tetradecane Pharmacology chemistry.chemical_classification Aza Compounds Mites Crystallography biology Strain (chemistry) Streptomycetaceae Fungi Glycosidic bond Stereoisomerism biology.organism_classification Streptomyces Molecular Weight chemistry Biochemistry Chromatography Gel Fermentation Actinomycetales Ethers |
| Zdroj: | The Journal of antibiotics. 45(4) |
| ISSN: | 0021-8820 |
| Popis: | AB3217-A, a novel anti-mite substance, was isolated from the fermentation broth of a streptomycete strain. The strain was isolated from a soil collected at Kita-azumi, Nagano Prefecture, Japan, and identified as Streptomyces platensis AB3217. AB3217-A was purified by Amberlite IR120B, Diaion HP-20 and CM-Sephadex C-25 column chromatographies. The molecular formula was determined as C17H23NO7 by elemental analysis, MS and 13C NMR spectroscopy. The structure of AB3217-A was determined to be (1R, 3S, 4S, -7R, 8R, 11R, 12S, 13R)-4, 12, 13-trihydroxy-8-(4-methoxyphenyl)-6-aza-2, 9, 14-trioxatncyclo-[9.2.1.03, 7]tetradecane by spectroscopic analysis and X-ray crystallographic analysis. The molecule of AB3217-A has unique structure that deacetylanisomycin and β-D-xylofuranose linked through glycosidic bond and ether bond resulting in the formation of nine-membered ring. AB3217-A showed marked activity against the two spotted spider mite, Tetranychus urticae. |
| Databáze: | OpenAIRE |
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