Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL-1-Mediated Mechanism

Autor: Patrick W. F. Hadoke, Alexander M.K. Rothman, Maria-Cruz Villa-Uriol, Sheila E. Francis, David C. Crossman, Junxi Wu, Janet Chamberlain, Torsten Schenkel, Mabruka Alfaidi, Paul C. Evans
Přispěvatelé: University of St Andrews. School of Medicine, University of St Andrews. Office of the Principal
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Apolipoprotein B
Mice
Knockout
ApoE
Interleukin-1beta
Anti-Inflammatory Agents
030204 cardiovascular system & hematology
Interleukin 1
Wall shear stress
0302 clinical medicine
Aorta
Original Research
biology
docosahexaenoic acid
Plaque
Atherosclerotic
3. Good health
Docosahexaenoic acid
medicine.anatomical_structure
RB Pathology
Hypertension
medicine.symptom
Cardiology and Cardiovascular Medicine
Signal Transduction
Cardiac function curve
medicine.medical_specialty
Endothelium
Docosahexaenoic Acids
endothelium
NDAS
Aortic Diseases
Inflammation
Diet
High-Fat
interleukin 1
Proinflammatory cytokine
03 medical and health sciences
Internal medicine
TA164
medicine
Animals
Arterial Pressure
business.industry
medicine.disease
Atherosclerosis
wall shear stress
Disease Models
Animal
030104 developmental biology
Endocrinology
Blood pressure
Atheroma
Animal Models of Human Disease
inflammation
Growth Factors/Cytokines
Dietary Supplements
biology.protein
Stress
Mechanical
business
RB
Basic Science Research
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association
Alfaidi, M A, Chamberlain, J, Rothman, A, Crossman, D, Villa-Uriol, M-C, Hadoke, P, Wu, J, Schenkel, T, Evans, P C & Francis, S E 2018, ' Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL-1-Mediated Mechanism ', Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, vol. 7, no. 13 . https://doi.org/10.1161/JAHA.118.008757
ISSN: 2047-9980
Popis: Background Hypertension is a complex condition and a common cardiovascular risk factor. Dietary docosahexaenoic acid ( DHA ) modulates atherosclerosis and hypertension, possibly via an inflammatory mechanism. IL‐1 (interleukin 1) has an established role in atherosclerosis and inflammation, although whether IL ‐1 inhibition modulates blood pressure is unclear. Methods and Results Male apoE −/− (apolipoprotein E–null) mice were fed either a high fat diet or a high fat diet plus DHA (300 mg/kg per day) for 12 weeks. Blood pressure and cardiac function were assessed, and effects of DHA on wall shear stress and atherosclerosis were determined. DHA supplementation improved left ventricular function, reduced wall shear stress and oscillatory shear at ostia in the descending aorta, and significantly lowered blood pressure compared with controls (119.5±7 versus 159.7±3 mm Hg, P DHA feeding in mice demonstrated a 4‐fold reduction in lesion burden in distal aortas and in brachiocephalic arteries ( P DHA treatment selectively decreased plaque endothelial IL ‐1β ( P Conclusions Our findings revealed that raised blood pressure can be reduced by inhibiting IL ‐1 indirectly by administration of DHA in the diet through a mechanism that involves a reduction in wall shear stress and local expression of the proinflammatory cytokine IL ‐1β.
Databáze: OpenAIRE
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