Recurrent isochromosome 21 and multiple abnormalities in a patient suspected of having acute myeloid leukemia with eosinophilic differentiation--a rare case from South India
| Autor: | Hariharan S, Sangeetha Vijay, Sureshkumar Raveendran, Leelakumari S, Syamala, Santhi Sarojam, Geetha Narayanan |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Monosomy Pathology medicine.medical_specialty Chromosomes Human Pair 21 Ring chromosome Isochromosome Chromosomal translocation Biology Leukemia Myelomonocytic Acute Translocation Genetic Polyploidy hemic and lymphatic diseases medicine Humans Philadelphia Chromosome Ring Chromosomes neoplasms tetraploid endoreduplication In Situ Hybridization Fluorescence X chromosome Aged Chromosome Aberrations Chromosomes Human Pair 14 Chromosome 7 (human) Multiple abnormalities Chromosomes Human X ring chromosome Myeloid leukemia i(21)(q10) Endoreduplication medicine.disease Case Research Isochromosomes Oncology Cytogenetic Analysis AML-M4 [E0] Chromosome Deletion atypical cytogenetic abnormalities Blast Crisis Chromosomes Human Pair 9 Chromosomes Human Pair 7 Chromosomes Human Pair 17 |
| Zdroj: | Chinese Journal of Cancer |
| ISSN: | 1944-446X 1000-467X |
| DOI: | 10.5732/cjc.011.10201 |
| Popis: | Acute myeloid leukemia (AML) is a phenotypically heterogeneous disorder. The M4 subtype of AML is frequently associated with the cytogenetic marker inversion 16 and/or the presence of eosinophilia. Blast crisis is the aggressive phase of the triphasic chronic myeloid leukemia (CML), which is a disease with Philadelphia (Ph) chromosome as the major abnormality. In the present study, we report a 76-year-old patient suspected of having AML with eosinophilic differentiation (AML-M4), which in clinical tests resembles CML blast crisis with multiple chromosomal abnormalities. Isochromosome 21 [i(21)(q10)] was the most recurrent feature noted in metaphases with 46 chromosomes. Ring chromosome, tetraploid endoreduplication, recurrent aneuploid clones with loss of X chromosome, monosomy 17, monosomy 7, and structural variation translocation (9;14) were also observed in this patient. Fluorescent in situ hybridization (FISH) confirmed the absence of Ph chromosome. This report shows how cytogenetic analyses revealed atypical structural aberrations in the M4 subtype of AML. |
| Databáze: | OpenAIRE |
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