Mevashuntin, a novel metabolite produced by inhibition of the mevalonate pathway in Streptomyces prunicolor

Autor:	Yukiko Umeda, Kazuo Furihata, Kazuo Shin-ya, Keiko Furihata, Yoichi Hayakawa, Shuhei Chijiwa, Haruo Seto
Rok vydání:	2005
Předmět:	Streptomyces prunicolor Metabolite Organic Chemistry General Medicine Conjugated system Reductase Biochemistry Naphthoquinone chemistry.chemical_compound chemistry Drug Discovery Mevalonate pathway Mevashuntin
Zdroj:	Tetrahedron Letters. 46:1273-1276
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2004.12.134
Popis:	Inhibition of the mevalonate pathway by an HMG-CoA reductase inhibitor, mevalotin, in Streptomyces prunicolor possessing both mevalonate and MEP pathways resulted in the production of a new metabolite mevashuntin that consisted of conjugated thiazolone and pyranonaphthoquinone moieties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf5e89b6fd26d7d50c5855340dfe1e4 https://doi.org/10.1016/j.tetlet.2004.12.134 Zobrazit plný text záznamu Full Text from ScienceDirect